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Descriptor English: Presenilins
Descriptor Spanish: Presenilinas
Descriptor Portuguese: Presenilinas
Descriptor French: Présénilines
Entry term(s): Presenilin
Tree number(s): D12.776.543.696
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053763
Scope note: Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Alzheimer Disease (1995-2006)
Membrane Proteins (1995-2006)
Public MeSH Note: 2007
History Note: 2007
DeCS ID: 52333
Unique ID: D053763
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2010/06/25
Presenilins - Preferred
Concept UI M0496221
Scope note Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.
Preferred term Presenilins
Entry term(s) Presenilin



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