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Descriptor English: Discs Large Homolog 1 Protein
Descriptor Spanish: Homólogo 1 de la Proteína Discs Large
Descriptor Portuguese: Proteína 1 Homóloga a Discs-Large
Descriptor French: Homologue-1 de la protéine Discs Large
Entry term(s): Synapse Associated Protein 97
Synapse-Associated Protein 97
Tree number(s): D08.811.913.696.650.450.500
D12.644.360.024.287
D12.776.157.057.023
D12.776.476.024.325
D12.776.543.213
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000074288
Scope note: A signaling adaptor protein that contains three PDZ DOMAINS; an SH3 DOMAIN; and a GUANYLATE KINASE-like C-terminal region. It has an essential role in animal development and recruits ion channels, receptors, and signaling molecules to discrete plasma membrane regions of polarized cells in the HEART ATRIA MYOCARDIUM. It functions in the assembly of ADHERENS JUNCTIONS and regulation of CELL PROLIFERATION; synaptogenesis, LYMPHOCYTE ACTIVATION; and controls expression of KV4 POTASSIUM CHANNELS to regulate excitability of CARDIAC MYOCYTES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Adaptor Proteins, Signal Transducing (2006-2017)
Membrane Proteins (2006-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57035
Unique ID: D000074288
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/27
Discs Large Homolog 1 Protein - Preferred
Concept UI M000625934
Scope note A signaling adaptor protein that contains three PDZ DOMAINS; an SH3 DOMAIN; and a GUANYLATE KINASE-like C-terminal region. It has an essential role in animal development and recruits ion channels, receptors, and signaling molecules to discrete plasma membrane regions of polarized cells in the HEART ATRIA MYOCARDIUM. It functions in the assembly of ADHERENS JUNCTIONS and regulation of CELL PROLIFERATION; synaptogenesis, LYMPHOCYTE ACTIVATION; and controls expression of KV4 POTASSIUM CHANNELS to regulate excitability of CARDIAC MYOCYTES.
Preferred term Discs Large Homolog 1 Protein
Entry term(s) Synapse Associated Protein 97
Synapse-Associated Protein 97



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