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Descriptor English: Protoporphyrinogen Oxidase
Descriptor Spanish: Protoporfirinógeno-Oxidasa
Descriptor protoporfirinógeno oxidasa
Scope note: Flavoenzima unida a la membrana que cataliza la aromatización del protoporfirinógeno IX (Protogén) a protoporfirina IX (Proto IX). Es la última enzima de la rama común de las vías del HEMO y de la CLOROFILA en las plantas y es la molécula sobre la que actúan los herbicidas de tipo difenil-éter. La PORFIRIA VARIEGATA es un trastorno autosómico dominante asociado a déficit de protoporfirinógeno-oxidasa.
Descriptor Portuguese: Protoporfirinogênio Oxidase
Descriptor French: Protoporphyrinogen oxidase
Entry term(s): Dehydrogenase, Protoporphyrinogen
Oxidase, Protoporphyrinogen
Oxidase, Protoporphyrinogen IX
Protoporphyrinogen Dehydrogenase
Protoporphyrinogen IX Oxidase
Protoporphyrinogenase
Protox
Tree number(s): D08.811.682.660.600
D12.776.543.697
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050768
Scope note: A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of protoporphyrinogen IX (Protogen) to protoporphyrin IX (Proto IX). It is the last enzyme of the common branch of the HEME and CHLOROPHYLL pathways in plants, and is the molecular target of diphenyl ether-type herbicides. VARIEGATE PORPHYRIA is an autosomal dominant disorder associated with deficiency of protoporphyrinogen oxidase.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Porphyria, Variegate
Registry Number: EC 1.3.3.4
Previous Indexing: Oxidoreductases (1993-2003)
Oxidoreductases Acting on CH-CH Group Donors (2004-2005)
Porphyrins (1975-1976)
Protoporphyrins (1975-1982)
Public MeSH Note: 2006; PROTOPORPHYRINOGEN OXIDASE was indexed under OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS 2004-2005, under OXIDOREDUCTASES 1993-2003, under PORPHYRINS 1975-1976, and under PROTOPORPHYRINS 1975-1982
History Note: 2006(1975)
DeCS ID: 50629
Unique ID: D050768
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2009/07/15
Protoporphyrinogen Oxidase - Preferred
Concept UI M0078571
Scope note A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of protoporphyrinogen IX (Protogen) to protoporphyrin IX (Proto IX). It is the last enzyme of the common branch of the HEME and CHLOROPHYLL pathways in plants, and is the molecular target of diphenyl ether-type herbicides. VARIEGATE PORPHYRIA is an autosomal dominant disorder associated with deficiency of protoporphyrinogen oxidase.
Preferred term Protoporphyrinogen Oxidase
Entry term(s) Dehydrogenase, Protoporphyrinogen
Oxidase, Protoporphyrinogen
Oxidase, Protoporphyrinogen IX
Protoporphyrinogen Dehydrogenase
Protoporphyrinogen IX Oxidase
Protoporphyrinogenase
Protox



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