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Descriptor English: DNA (Cytosine-5-)-Methyltransferase 1
Descriptor Spanish: ADN (Citosina-5-)-Metiltransferasa 1
Descriptor ADN (citosina-5-)-metiltransferasa 1
Entry term(s) enzima DNMT1
Scope note: ADN (citosina-5)-metiltransferasa que contiene un motivo central de dedo de zinc tipo CxxC. Se une a poli(ADP)-ribosa y su expresión es regulada por la POLI (ADP-RIBOSA) POLIMERASA-1. La DNMT1 metila residuos CpG, con preferencia por el ADN hemimetilado y se asocia a los sitios de replicación del ADN en la FASE S para mantener el patrón de metilación en la hebra recién fabricada, lo que resulta esencial en los PROCESOS EPIGENÉTICOS. También se asocia a la CROMATINA durante la FASE G2 y la MITOSIS para mantener la metilación independientemente de la replicación. Es responsable del mantenimiento de los patrones de metilación establecidos durante el desarrollo; las mutaciones del gen DNMT1 se asocian a la NEUROPATÍA HEREDITARIA SENSORIAL TIPO 1, clase E.
Descriptor Portuguese: DNA (Citosina-5-)-Metiltransferase 1
Descriptor French: DNA (Cytosine-5-)-methyltransferase 1
Entry term(s): ADN (Cytosine-5-)-méthyltransférase-1
Enzyme DNMT1
Tree number(s): D08.811.913.555.500.350.100.500.500
D12.776.157.687.313
D12.776.660.720.313
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000076123
Scope note: A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE) POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated DNA, and associates with DNA replication sites in S PHASE to maintain the methylation pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES. It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development; mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E.
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Registry Number: EC 2.1.1.37
Related: Doigts de zinc MeSH
DeCS ID: 57029
Unique ID: D000076123
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
DNA (Cytosine-5-)-methyltransferase 1 - Preferred
Concept UI M0336557
Preferred term DNA (Cytosine-5-)-methyltransferase 1
Entry term(s) ADN (Cytosine-5-)-méthyltransférase-1
Enzyme DNMT1



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