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Descriptor English: Prions
Descriptor Spanish: Priones
Descriptor priones
Entry term(s) prion
proteínas de priones
virus de la encefalopatía del visón
Scope note: Pequeñas partículas infecciosas proteináceas que resisten la inactivación por procedimientos que modifican los ÁCIDOS NUCLEICOS y que contienen una isoforma anormal de una proteína celular que es un componente importante y necesario. La isoforma anormal (precursora) es PrPSc (PROTEÍNAS PRPSC) y la isoforma celular PrPC (PROTEÍNAS PRPC). La secuencia primaria de aminoácidos de las dos isoformas es idéntica. Entre las enfermedades humanas producidas por priones se encuentran el SÍNDROME DE CREUTZFELDT-JAKOB, la ENFERMEDAD DE GERSTMANN-STRAUSSLER-SCHEINKER y el INSOMNIO FAMILIAR MORTAL.
Descriptor Portuguese: Príons
Descriptor French: Prions
Entry term(s): Encephalopathy Virus, Mink
Mink Encephalopathy Virus
Prion
Tree number(s): D12.776.785
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011328
Scope note: Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
PY pathogenicity
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: PrPSc Proteins (1966-1985)
Viral Proteins (1966-1985)
Public MeSH Note: 86; MINK ENCEPHALOPATHY VIRUS was heading 1991-92, was see under VERTEBRATE VIRUSES, UNCLASSIFIED (now VIRUSES, UNCLASSIFIED) 1975-90; TRANSMISSIBLE ENCEPHALOPATHY VIRUS OF MINK was see MINK ENCEPHALOPATHY VIRUS 1975-92
Online Note: use PRIONS to search MINK ENCEPHALOPATHY VIRUS & TRANSMISSIBLE ENCEPHALOPATHY VIRUS OF MINK 1975-92
History Note: 86; MINK ENCEPHALOPATHY VIRUS was heading 1991-92, was see under VERTEBRATE VIRUSES, UNCLASSIFIED (now VIRUSES, UNCLASSIFIED) 1975-90; TRANSMISSIBLE ENCEPHALOPATHY VIRUS OF MINK was see MINK ENCEPHALOPATHY VIRUS 1975-92
DeCS ID: 19524
Unique ID: D011328
NLM Classification: QU 55
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1985/05/10
Revision Date: 2020/05/27
Prions - Preferred
Concept UI M0017586
Scope note Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
Preferred term Prions
Entry term(s) Prion
Mink Encephalopathy Virus - Narrower
Concept UI M0017585
Preferred term Mink Encephalopathy Virus
Entry term(s) Encephalopathy Virus, Mink



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