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Descriptor English: Kininogens
Descriptor Spanish: Quininógenos
Descriptor cininógenos
Entry term(s) quininógenos
Scope note: Péptidos endógenos presentes en la mayoría de los líquidos corporales. Ciertas enzimas los convierten en CININAS activas que intervienen en la inflamación, coagulación sanguínea, reacciones del complemento, etc. Los cininógenos pertenecen a la superfamilia de las cistatinas. Son inhibidores de la cisteína proteinasa. El CININÓGENO DE ALTO PESO MOLECULAR (HMWK) es escindido por la calicreína del plasma para producir BRADICININA. El CININÓGENO DE BAJO PESO MOLECULAR es escindido por la calicreína tisular produciendo CALIDINA.
Descriptor Portuguese: Cininogênios
Descriptor French: Kininogènes
Entry term(s): Kininogène
Kininogène T
T-Kininogène
Thiostatine
Tree number(s): D12.644.276.812.654
D12.776.124.125.635
D12.776.467.812.654
D12.776.811.420
D23.119.630
D23.469.050.375.425
D23.529.812.654
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007704
Scope note: Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.
Annotation: cysteine proteinase inhib; /drug eff /physiol permitted
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Cysteine Proteinase Inhibitors
DeCS ID: 28118
Unique ID: D007704
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2006/07/05
Kininogènes - Preferred
Concept UI M0012050
Preferred term Kininogènes
Kininogène T - Narrower
Concept UI M0012051
Preferred term Kininogène T
Entry term(s) T-Kininogène
Thiostatine - Narrower
Concept UI M0012053
Preferred term Thiostatine
Kininogène - Narrower
Concept UI M0012052
Preferred term Kininogène



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