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Descriptor English: Calcineurin
Descriptor Spanish: Calcineurina
Descriptor calcineurina
Entry term(s) PP2B
calcineurina A
calcineurina B
proteína fosfatasa-2B
proteína-fosfatasa 2B
Scope note: Proteína serina-treonina fosfatasa dependiente de CALMODULINA y CALCIO que está compuesta por una subunidad catalítica, la calcineurina A, y una subnidad reguladora, la calcineurina B. Se ha demostrado que la calcineurina defosforila un numeroso grupo de fosfoproteínas, entre ellas las HISTONAS, la CADENA LIGERA DE MIOSINA y las subunidades reguladoras de las PROTEÍNA CINASAS DEPENDIENTES DE AMP CÍCLICO. Está implicada en la regulación de la transducción de señal y es la diana de una clase importante de fármacos complejos inmunofilina- inmunosupresor.
Descriptor Portuguese: Calcineurina
Descriptor French: Calcineurine
Entry term(s): Calcineurin A
Calcineurin B
Phosphatase 3, Protein
Protein Phosphatase 2B
Protein Phosphatase 3
Protein Phosphatase 3 Catalytic Subunit
Protein Phosphatase 3 Regulatory Subunit
Protein Phosphatase-2B
Tree number(s): D08.811.277.352.650.625.150
D12.644.360.087
D12.776.476.559.150
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019703
Scope note: A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Calcineurin Inhibitors
Registry Number: EC 3.1.3.16
Previous Indexing: Calcium-Binding Proteins (1986-1997)
Calmodulin-Binding Proteins (1986-1997)
Phosphoprotein Phosphatase (1988-1997)
Public MeSH Note: 98; CALCINEURIN was indexed under PHOSPHOPROTEIN PHOSPHATASE 1988-97 & CALMODULIN-BINDING PROTEINS 1986-97; CALCINEURIN B (now CALCINEURIN) was indexed under CALCIUM-BINDING PROTEINS 1994-97
History Note: 98; see CALCINEURIN (NM) 1987-97
DeCS ID: 33429
Unique ID: D019703
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2015/11/23
Calcineurin - Preferred
Concept UI M0029257
Scope note A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Preferred term Calcineurin
Entry term(s) Phosphatase 3, Protein
Protein Phosphatase 2B
Protein Phosphatase 3
Protein Phosphatase-2B
Calcineurin B - Narrower
Concept UI M0029258
Preferred term Calcineurin B
Entry term(s) Protein Phosphatase 3 Regulatory Subunit
Calcineurin A - Narrower
Concept UI M0029259
Preferred term Calcineurin A
Entry term(s) Protein Phosphatase 3 Catalytic Subunit



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