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Descriptor English: Smad4 Protein
Descriptor Spanish: Proteína Smad4
Descriptor proteína smad4
Scope note: Proteína adaptadora de transducción de señales y proteína supresora de tumores. Forma un complejo con las PROTEÍNAS SMAD REGULADAS POR RECEPTORES activadas. A continuación el complejo se transloca al NÚCLEO CELULAR y regula la TRANSCRIPCIÓN GENÉTICA de los GENES diana.
Descriptor Portuguese: Proteína Smad4
Descriptor French: Protéine Smad-4
Entry term(s): Common Smad
MADH4 Protein
Smad, Common
Tree number(s): D12.644.360.024.334.750
D12.776.157.057.170.750
D12.776.260.713.750
D12.776.476.024.428.750
D12.776.624.776.760
D12.776.930.806.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D051901
Scope note: A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006; SMAD4 PROTEIN was indexed under DNA-BINDING PROTEINS & TRANS-ACTIVATORS 1997-2005, & under PROTEINS 1996
History Note: 2006(1996)
DeCS ID: 50794
Unique ID: D051901
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2016/02/18
Smad4 Protein - Preferred
Concept UI M0482114
Scope note A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.
Preferred term Smad4 Protein
Entry term(s) Common Smad
MADH4 Protein
Smad, Common



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