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Descriptor English: Urokinase-Type Plasminogen Activator
Descriptor Spanish: Activador de Plasminógeno de Tipo Uroquinasa
Descriptor Portuguese: Ativador de Plasminogênio Tipo Uroquinase
Descriptor French: Activateur du plasminogène de type urokinase
Entry term(s): Abbokinase
Kidney Plasminogen Activator
Plasminogen Activator, Urokinase-Type
Renokinase
Single Chain Urokinase Type Plasminogen Activator
Single-Chain Urokinase-Type Plasminogen Activator
U Plasminogen Activator
U-PA
U-Plasminogen Activator
Urinary Plasminogen Activator
Urokinase
Urokinase Type Plasminogen Activator
Tree number(s): D08.811.277.656.300.760.910
D08.811.277.656.959.350.910
D12.776.124.125.662.884
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D014568
Scope note: A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.21.73
Previous Indexing: Fibrinolytic Agents (1966-1974)
Public MeSH Note: 2009; see URINARY PLASMINOGEN ACTIVATOR 2000-2008, see UROKINASE 1984-1999, see PEPTIDE PEPTIDOHYDROLASES 1975-1983, see FIBRINOLYTIC AGENTS 1966-1974, see STREPTODORNASE AND STREPTOKINASE 1963-1965; UROKINASE-TYPE PLASMINOGEN ACTIVATOR was indexed under PLASMINOGEN ACTIVATORS & UROKINASE 1984-1999
History Note: 2009(1963)
DeCS ID: 23502
Unique ID: D014568
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1984/01/01
Date of Entry: 1999/01/01
Revision Date: 2009/07/06
Urokinase-Type Plasminogen Activator - Preferred
Concept UI M0022396
Scope note A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.
Preferred term Urokinase-Type Plasminogen Activator
Entry term(s) Plasminogen Activator, Urokinase-Type
U Plasminogen Activator
U-PA
U-Plasminogen Activator
Urinary Plasminogen Activator
Urokinase
Urokinase Type Plasminogen Activator
Renokinase - Narrower
Concept UI M0333863
Preferred term Renokinase
Abbokinase - Narrower
Concept UI M0333864
Preferred term Abbokinase
Kidney Plasminogen Activator - Narrower
Concept UI M0022397
Preferred term Kidney Plasminogen Activator
Single-Chain Urokinase-Type Plasminogen Activator - Narrower
Concept UI M0022398
Preferred term Single-Chain Urokinase-Type Plasminogen Activator
Entry term(s) Single Chain Urokinase Type Plasminogen Activator



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