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Descriptor English: Factor XIa
Descriptor Spanish: Factor XIa
Descriptor Portuguese: Fator XIa
Descriptor French: Facteur XIa
Entry term(s): Activated Factor XI
Blood Coagulation Factor XI, Activated
Coagulation Factor XIa
Contact Activation Product
Factor 11A
Factor Eleven A
Factor XI, Activated
Factor XIa, Coagulation
Tree number(s): D08.811.277.656.300.760.320
D08.811.277.656.959.350.320
D12.776.124.125.425.320
D23.119.425.320
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015945
Scope note: Activated form of factor XI. In the intrinsic pathway, Factor XI is activated to XIa by factor XIIa in the presence of cofactor HMWK; (HIGH MOLECULAR WEIGHT KININOGEN). Factor XIa then activates factor IX to factor IXa in the presence of calcium.
Annotation: /defic = FACTOR XI DEFICIENCY
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.21.27
Previous Indexing: Factor XI (1972-1989)
Serine Proteinases (1988-1989)
Public MeSH Note: 90
History Note: 90
Related: Coagulants MeSH
DeCS ID: 24647
Unique ID: D015945
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/09/06
Revision Date: 2017/02/24
Factor XIa - Preferred
Concept UI M0024393
Scope note Activated form of factor XI. In the intrinsic pathway, Factor XI is activated to XIa by factor XIIa in the presence of cofactor HMWK; (HIGH MOLECULAR WEIGHT KININOGEN). Factor XIa then activates factor IX to factor IXa in the presence of calcium.
Preferred term Factor XIa
Entry term(s) Activated Factor XI
Blood Coagulation Factor XI, Activated
Coagulation Factor XIa
Contact Activation Product
Factor 11A
Factor Eleven A
Factor XI, Activated
Factor XIa, Coagulation



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