| Descriptor English: | High-Temperature Requirement A Serine Peptidase 1 | ||||||
| Descriptor Spanish: |
Serina Peptidasa A1 que Requiere Temperaturas Altas
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| Descriptor Portuguese: | Serina Peptidase 1 de Requerimento de Alta Temperatura A | ||||||
| Descriptor French: | High-temperature requirement A serine peptidase 1 | ||||||
| Entry term(s): |
HTRA1, Serine Protease High Temperature Requirement A Serine Peptidase 1 Protease HTRA1, Serine Serine Protease HTRA1 |
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| Tree number(s): |
D08.811.277.656.300.760.420 D08.811.277.656.959.350.420 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000074289 | ||||||
| Scope note: | A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL). |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 3.4.21.- | ||||||
| Previous Indexing: |
Serine Endopeptidases (2003-2017) |
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| Public MeSH Note: | 2018 |
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| History Note: | 2018 |
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| Related: |
Kazal Motifs
MeSH PDZ Domains MeSH | ||||||
| DeCS ID: | 57007 | ||||||
| Unique ID: | D000074289 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/06/01 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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High-Temperature Requirement A Serine Peptidase 1
- Preferred
| Concept UI |
M000625936 |
| Scope note | A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL). |
| Preferred term | High-Temperature Requirement A Serine Peptidase 1 |
| Entry term(s) |
HTRA1, Serine Protease High Temperature Requirement A Serine Peptidase 1 Protease HTRA1, Serine Serine Protease HTRA1 |
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