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Descriptor English: High-Temperature Requirement A Serine Peptidase 1
Descriptor Spanish: Serina Peptidasa A1 que Requiere Temperaturas Altas
Descriptor Portuguese: Serina Peptidase 1 de Requerimento de Alta Temperatura A
Descriptor French: High-temperature requirement A serine peptidase 1
Entry term(s): HTRA1, Serine Protease
High Temperature Requirement A Serine Peptidase 1
Protease HTRA1, Serine
Serine Protease HTRA1
Tree number(s): D08.811.277.656.300.760.420
D08.811.277.656.959.350.420
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000074289
Scope note: A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.21.-
Previous Indexing: Serine Endopeptidases (2003-2017)
Public MeSH Note: 2018
History Note: 2018
Related: Kazal Motifs MeSH
PDZ Domains MeSH
DeCS ID: 57007
Unique ID: D000074289
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/01
High-Temperature Requirement A Serine Peptidase 1 - Preferred
Concept UI M000625936
Scope note A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).
Preferred term High-Temperature Requirement A Serine Peptidase 1
Entry term(s) HTRA1, Serine Protease
High Temperature Requirement A Serine Peptidase 1
Protease HTRA1, Serine
Serine Protease HTRA1



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