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Descriptor English: Proliferating Cell Nuclear Antigen
Descriptor Spanish: Antígeno Nuclear de Célula en Proliferación
Descriptor antígeno nuclear de proliferación celular
Entry term(s) PCNA
Scope note: Antígeno nuclear que juega un papel en la síntesis y reparación del ADN, y en la progresión del ciclo celular. El ANCP se requiere para la síntesis coordinada de las cadenas conducida y conductora en la horquilla de replicación durante la replicación del ADN. La expresión del ANCP se correlaciona con la actividad de proliferación de varios tipos celulares malignos y no malignos.
Descriptor Portuguese: Antígeno Nuclear de Célula em Proliferação
Descriptor French: Antigène nucléaire de prolifération cellulaire
Entry term(s): Antigen, Proliferating Cell Nuclear
PCNA
Tree number(s): D12.776.660.740
D23.050.290.750
D23.101.140.600
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018809
Scope note: Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Nuclear Proteins (1988-1994)
Nucleoproteins (1983-1987)
Public MeSH Note: 95; PROLIFERATING CELL NUCLEAR ANTIGEN was indexed under NUCLEAR PROTEINS 1988-94 & NUCLEOPROTEINS 1983-87
Online Note: use PROLIFERATING CELL NUCLEAR ANTIGEN (NM) to search PROLIFERATING CELL NUCLEAR ANTIGEN 1983-94
History Note: 95; was PROLIFERATING CELL NUCLEAR ANTIGEN (NM) 1983-94
DeCS ID: 32064
Unique ID: D018809
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1995/01/01
Date of Entry: 1994/05/31
Revision Date: 2015/06/19
Proliferating Cell Nuclear Antigen - Preferred
Concept UI M0028162
Scope note Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Preferred term Proliferating Cell Nuclear Antigen
Entry term(s) Antigen, Proliferating Cell Nuclear
PCNA



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