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Descriptor English: Dystrophin
Descriptor Spanish: Distrofina
Descriptor distrofina
Scope note: Proteína muscular localizada en las membranas de superficie, que es el producto del gen de la distrofia muscular de Duchenne/Becker. Los individuos con distrofia muscular de Duchenne por lo general carecen totalmente de distrofina, mientras que aquellos con distrofia muscular de Becker tienen una cantidad alterada de distrofina. Comparte las características de otras proteínas citoesqueléticas como la ESPECTRINA y la alfa-actitinina, pero la función precisa de la distrofina no está clara. Un posible papel podría ser preservar la integridad y alineamiento de la membrana plasmática a las miofibrillas durante la contracción y la relajación muscular. PM 400 kD.
Descriptor Portuguese: Distrofina
Descriptor French: Dystrophine
Tree number(s): D12.776.210.500.250
D12.776.220.250
D12.776.543.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016189
Scope note: A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.
Annotation: a muscle protein: see MeSH definition for relation to musc dystrophy; /biosyn /drug eff /physiol /ultrastruct permitted
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Muscle Proteins (1988-1990)
Public MeSH Note: 91
History Note: 91
Related: Mice, Inbred mdx MeSH
Muscular Dystrophy, Duchenne MeSH
DeCS ID: 28916
Unique ID: D016189
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/06/17
Revision Date: 1999/11/03
Dystrophin - Preferred
Concept UI M0024706
Scope note A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.
Preferred term Dystrophin



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