| Descriptor English: | Mannose-Binding Protein-Associated Serine Proteases | ||||||
| Descriptor Spanish: |
Serina Proteasas Asociadas a la Proteína de Unión a la Manosa
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| Descriptor Portuguese: | Serina Proteases Associadas a Proteína de Ligação a Manose | ||||||
| Descriptor French: | Mannose-Binding Protein-Associated Serine Proteases | ||||||
| Entry term(s): |
MASP MASP Proteases MASP Related Protein MASP-Related Protein MASPs MBL Associated Serine Proteases MBL-Associated Serine Proteases MBP Associated Serine Protease MBP Associated Serine Protease Related Protein MBP-Associated Serine Protease MBP-Associated Serine Protease-Related Protein Mannan Binding Lectin Serine Proteases Mannan-Binding Lectin Serine Proteases Mannose Binding Protein Associated Serine Protease Mannose-Binding Protein-Associated Serine Protease Proteases, MASP Protein, MASP-Related Serine Protease, MBP-Associated Serine Proteases, MBL-Associated |
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| Tree number(s): |
D08.811.277.656.300.760.501 D08.811.277.656.959.350.501 D12.776.124.486.274.045.387.875 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D050606 | ||||||
| Scope note: | Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE. |
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| Annotation: | see SCR for organism-specific terms |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Pharm Action: |
Immunologic Factors |
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| Registry Number: | EC 3.4.21.- | ||||||
| Previous Indexing: |
Mannose-Binding Lectins (1992-2005) Serine Endopeptidases (1992-2005) |
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| Public MeSH Note: | 2006; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES was indexed under SERINE ENDOPEPTIDASES 1994-2005 |
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| History Note: | 2006 (1994) |
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| DeCS ID: | 50582 | ||||||
| Unique ID: | D050606 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2006/01/01 | ||||||
| Date of Entry: | 2005/06/30 | ||||||
| Revision Date: | 2020/06/17 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Mannose-Binding Protein-Associated Serine Proteases
- Preferred
MASP-Related Protein
- Related but not broader or narrower
| Concept UI |
M0233323 |
| Scope note | Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE. |
| Preferred term | Mannose-Binding Protein-Associated Serine Proteases |
| Entry term(s) |
MASP MASP Proteases MASPs MBL Associated Serine Proteases MBL-Associated Serine Proteases MBP Associated Serine Protease MBP-Associated Serine Protease Mannan Binding Lectin Serine Proteases Mannan-Binding Lectin Serine Proteases Mannose Binding Protein Associated Serine Protease Mannose-Binding Protein-Associated Serine Protease Proteases, MASP Serine Protease, MBP-Associated Serine Proteases, MBL-Associated |
| Concept UI |
M0361077 |
| Preferred term | MASP-Related Protein |
| Entry term(s) |
MASP Related Protein MBP Associated Serine Protease Related Protein MBP-Associated Serine Protease-Related Protein Protein, MASP-Related |
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