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Descriptor English: Fibrinogen
Descriptor Spanish: Fibrinógeno
Descriptor Portuguese: Fibrinogênio
Descriptor French: Fibrinogène
Entry term(s): Blood Coagulation Factor I
Coagulation Factor I
Factor I
Factor I, Coagulation
gamma Fibrinogen
gamma-Fibrinogen
Tree number(s): D12.776.124.050.250
D12.776.124.125.500
D12.776.811.300
D23.119.490
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005340
Scope note: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Annotation: a blood coag factor: do not confuse X ref FACTOR I with COMPLEMENT FACTOR I
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Afibrinogenemia
Registry Number: 9001-32-5
CAS Type 1 Name: Fibrinogens
Related: Coagulants MeSH
Hemostatics MeSH
DeCS ID: 22179
Unique ID: D005340
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/28
Fibrinogen - Preferred
Concept UI M0008430
Scope note Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Preferred term Fibrinogen
Entry term(s) Blood Coagulation Factor I
Coagulation Factor I
Factor I
Factor I, Coagulation
gamma-Fibrinogen - Narrower
Concept UI M0008431
Preferred term gamma-Fibrinogen
Entry term(s) gamma Fibrinogen



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