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Descriptor English: Complement Factor I
Descriptor Spanish: Factor I de Complemento
Descriptor factor I del complemento
Scope note: Serina proteinasa plasmática que escinde las cadenas alfa del C3b y C4b en presencia de los cofactores FACTOR H DEL COMPLEMENTO y proteína de unión a C4, respectivamente. Es una glicoproteína de 66 kDa que convierte el C3b en C3b inactivado (iC3b) seguido por la liberación de dos fragmentos, C3c (150 kDa) y C3dg (41 kDa). Anteriormente se lo denominó KAF C3bINF o inactivador enzimático 3b.
Descriptor Portuguese: Fator I do Complemento
Descriptor French: Facteur I du complément
Entry term(s): Inactivateur C3b-C4b
Inactivateur des fragments C3b-C4b du complément
Inactivateur du C3b
Tree number(s): D08.811.277.656.300.760.210
D08.811.277.656.959.350.210
D12.776.124.486.274.920.325.210
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D017244
Scope note: A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.
Annotation: do not confuse with FACTOR I see FIBRINOGEN
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Pharm Action: Complement Inactivating Agents
Registry Number: EC 3.4.21.45
DeCS ID: 30774
Unique ID: D017244
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1993/01/01
Date of Entry: 1992/05/07
Revision Date: 2009/07/06
Facteur I du complément - Preferred
Concept UI M0026165
Preferred term Facteur I du complément
Entry term(s) Inactivateur C3b-C4b
Inactivateur des fragments C3b-C4b du complément
Inactivateur du C3b



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