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Descriptor English: 14-3-3 Proteins
Descriptor Spanish: Proteínas 14-3-3
Descriptor proteínas 14-3-3
Scope note: Amplia familia de proteínas adaptadoras transductoras de señales presentes en una gran variedad de eucariotas. Son proteínas que se unen a la FOSFOSERINA y la FOSFOTREONINA, implicadas en importantes procesos celulares, como la TRANSDUCCIÓN DE SEÑALES, el control del CICLO CELULAR, la APOPTOSIS y las respuestas celulares al estrés. Las proteínas 14-3-3 interactúan con otras proteínas de transducción de señales y efectúan cambios en su actividad enzimática y localización subcelular. El nombre 14-3-3 deriva de las designaciones numéricas utilizadas en los patrones de fraccionamiento originales de las proteínas.
Descriptor Portuguese: Proteínas 14-3-3
Descriptor French: Protéines 14-3-3
Entry term(s): 14 3 3 Protein
14 3 3 Protein, beta Isoform
14 3 3 Protein, epsilon Isoform
14 3 3 Protein, eta Isoform
14 3 3 Protein, gamma Isoform
14 3 3 Protein, tau Isoform
14 3 3 Protein, zeta Isoform
14 3 3 Proteins
14 3 3 beta Protein
14 3 3 epsilon Protein
14 3 3 eta Protein
14 3 3 gamma Protein
14 3 3 tau Protein
14 3 3 zeta Protein
14 3 3beta Protein
14 3 3epsilon Protein
14 3 3eta Protein
14 3 3gamma Protein
14 3 3tau Protein
14 3 3zeta Protein
14-3-3 Protein
14-3-3 Protein, Brain
14-3-3 Protein, beta Isoform
14-3-3 Protein, epsilon Isoform
14-3-3 Protein, eta Isoform
14-3-3 Protein, gamma Isoform
14-3-3 Protein, tau Isoform
14-3-3 Protein, zeta Isoform
14-3-3 beta Protein
14-3-3 epsilon Protein
14-3-3 eta Protein
14-3-3 gamma Protein
14-3-3 tau Protein
14-3-3 zeta Protein
14-3-3beta Protein
14-3-3epsilon Protein
14-3-3eta Protein
14-3-3gamma Protein
14-3-3tau Protein
14-3-3zeta Protein
Brain 14 3 3 Protein
Brain 14-3-3 Protein
Protein 14-3-3
Protein, 14-3-3tau
eta Protein, 14-3-3
Tree number(s): D12.644.360.024.050
D12.776.157.057.002
D12.776.476.024.050
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D048948
Scope note: A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Nerve Tissue Proteins (1981-1994)
Proteins (1995-1999)
Tyrosine 3-Monooxygenase (2000-2004)
Public MeSH Note: 2005; 14-3-3 PROTEINS was indexed under TYROSINE 3-MONOOXYGENASE 2000-2004, under PROTEINS 1995-1999, & under NERVE TISSUE PROTEINS 1981-1994
History Note: 2005(1981)
DeCS ID: 38740
Unique ID: D048948
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2005/01/01
Date of Entry: 2004/07/07
Revision Date: 2015/11/23
14-3-3 Proteins - Preferred
Concept UI M0091246
Scope note A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.
Preferred term 14-3-3 Proteins
Entry term(s) 14 3 3 Protein
14 3 3 Proteins
14-3-3 Protein
14-3-3 Protein, Brain
Brain 14 3 3 Protein
Brain 14-3-3 Protein
Protein 14-3-3
14-3-3 Protein, tau Isoform - Narrower
Concept UI M0091236
Preferred term 14-3-3 Protein, tau Isoform
Entry term(s) 14 3 3 Protein, tau Isoform
14 3 3 tau Protein
14 3 3tau Protein
14-3-3 tau Protein
14-3-3tau Protein
Protein, 14-3-3tau
14-3-3 Protein, zeta Isoform - Narrower
Concept UI M0091237
Preferred term 14-3-3 Protein, zeta Isoform
Entry term(s) 14 3 3 Protein, zeta Isoform
14 3 3 zeta Protein
14 3 3zeta Protein
14-3-3 zeta Protein
14-3-3zeta Protein
14-3-3 Protein, eta Isoform - Narrower
Concept UI M0439854
Preferred term 14-3-3 Protein, eta Isoform
Entry term(s) 14 3 3 Protein, eta Isoform
14 3 3 eta Protein
14 3 3eta Protein
14-3-3 eta Protein
14-3-3eta Protein
eta Protein, 14-3-3
14-3-3 Protein, epsilon Isoform - Narrower
Concept UI M0363270
Preferred term 14-3-3 Protein, epsilon Isoform
Entry term(s) 14 3 3 Protein, epsilon Isoform
14 3 3 epsilon Protein
14 3 3epsilon Protein
14-3-3 epsilon Protein
14-3-3epsilon Protein
14-3-3 Protein, gamma Isoform - Narrower
Concept UI M0091234
Preferred term 14-3-3 Protein, gamma Isoform
Entry term(s) 14 3 3 Protein, gamma Isoform
14 3 3 gamma Protein
14 3 3gamma Protein
14-3-3 gamma Protein
14-3-3gamma Protein
14-3-3 Protein, beta Isoform - Narrower
Concept UI M0439853
Preferred term 14-3-3 Protein, beta Isoform
Entry term(s) 14 3 3 Protein, beta Isoform
14 3 3 beta Protein
14 3 3beta Protein
14-3-3 beta Protein
14-3-3beta Protein



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