| Descriptor English: | Dishevelled Proteins | ||||||
| Descriptor Spanish: |
Proteínas Dishevelled
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| Descriptor Portuguese: | Proteínas Desgrenhadas | ||||||
| Descriptor French: | Protéines Dishevelled | ||||||
| Entry term(s): |
Dishevelled 1 Protein Dishevelled 2 Protein Dishevelled 3 Protein Dishevelled Protein Dishevelled-1 Protein Dishevelled-2 Protein Dishevelled-3 Protein |
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| Tree number(s): |
D12.644.360.024.288 D12.776.157.057.028 D12.776.476.024.330 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000072261 | ||||||
| Scope note: | A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Public MeSH Note: | 2017; DISHEVELLED PROTEINS was indexed under ADAPTOR PROTEINS, SIGNAL TRANSDUCING 2006-2016; under PHOSPHOPROTEINS 1998-2016; and under PROTEINS 1994-1997 |
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| History Note: | 2017 (1994) |
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| DeCS ID: | 56535 | ||||||
| Unique ID: | D000072261 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2017/05/24 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Dishevelled Proteins
- Preferred
Dishevelled-3 Protein
- Narrower
Dishevelled-1 Protein
- Narrower
Dishevelled-2 Protein
- Narrower
| Concept UI |
M0226765 |
| Scope note | A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY. |
| Preferred term | Dishevelled Proteins |
| Entry term(s) |
Dishevelled Protein |
| Concept UI |
M000616700 |
| Preferred term | Dishevelled-3 Protein |
| Entry term(s) |
Dishevelled 3 Protein |
| Concept UI |
M000616698 |
| Preferred term | Dishevelled-1 Protein |
| Entry term(s) |
Dishevelled 1 Protein |
| Concept UI |
M000616699 |
| Preferred term | Dishevelled-2 Protein |
| Entry term(s) |
Dishevelled 2 Protein |
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