| Descriptor English: | Insulin Receptor Substrate Proteins | ||||
| Descriptor Spanish: |
Proteínas Sustrato del Receptor de Insulina
| ||||
| Descriptor Portuguese: | Proteínas Substratos do Receptor de Insulina | ||||
| Descriptor French: | Substrats du récepteur à l'insuline | ||||
| Entry term(s): |
IRS Signaling Adaptor Proteins Insulin Receptor Substrate 1 Insulin Receptor Substrate 1 Protein Insulin Receptor Substrate 2 Insulin Receptor Substrate 2 Protein Insulin Receptor Substrate 3 Insulin Receptor Substrate 3 Protein Insulin Receptor Substrate 4 Insulin Receptor Substrate 4 Protein Insulin Receptor Substrate-1 Insulin Receptor Substrate-1 Protein Insulin Receptor Substrate-2 Insulin Receptor Substrate-2 Protein Insulin Receptor Substrate-3 Insulin Receptor Substrate-3 Protein Insulin Receptor Substrate-4 Insulin Receptor Substrate-4 Protein |
||||
| Tree number(s): |
D12.644.360.024.301 D12.776.157.057.045 D12.776.476.024.382 |
||||
| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D055504 | ||||
| Scope note: | A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling. |
||||
| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
||||
| Previous Indexing: |
Adaptor Proteins, Signal Transducing (2008) Phosphoproteins (1992-2008) |
||||
| Public MeSH Note: | 2009; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN was indexed under PHOSPHOPROTEINS 1992-2008, & under ADAPTOR PROTEINS, SIGNAL TRANSDUCING 2008; INSULIN RECEPTOR SUBSTRATE-2 PROTEIN was indexed under PHOSPHOPROTEINS 1995-2008, & under ADAPTOR PROTEINS, SIGNAL TRANSDUCING 2008 |
||||
| History Note: | 2009(1992) |
||||
| DeCS ID: | 53148 | ||||
| Unique ID: | D055504 | ||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||
| Date Established: | 2009/01/01 | ||||
| Date of Entry: | 2008/07/08 | ||||
| Revision Date: | 2017/05/24 |
-
-
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
|
|
Insulin Receptor Substrate Proteins
- Preferred
Insulin Receptor Substrate-1 Protein
- Narrower
Insulin Receptor Substrate-4 Protein
- Narrower
Insulin Receptor Substrate-2 Protein
- Narrower
Insulin Receptor Substrate-3 Protein
- Narrower
| Concept UI |
M0518076 |
| Scope note | A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling. |
| Preferred term | Insulin Receptor Substrate Proteins |
| Entry term(s) |
IRS Signaling Adaptor Proteins |
| Concept UI |
M0198035 |
| Preferred term | Insulin Receptor Substrate-1 Protein |
| Entry term(s) |
Insulin Receptor Substrate 1 Insulin Receptor Substrate 1 Protein Insulin Receptor Substrate-1 |
| Concept UI |
M0518133 |
| Preferred term | Insulin Receptor Substrate-4 Protein |
| Entry term(s) |
Insulin Receptor Substrate 4 Insulin Receptor Substrate 4 Protein Insulin Receptor Substrate-4 |
| Concept UI |
M0251739 |
| Preferred term | Insulin Receptor Substrate-2 Protein |
| Entry term(s) |
Insulin Receptor Substrate 2 Insulin Receptor Substrate 2 Protein Insulin Receptor Substrate-2 |
| Concept UI |
M0518132 |
| Preferred term | Insulin Receptor Substrate-3 Protein |
| Entry term(s) |
Insulin Receptor Substrate 3 Insulin Receptor Substrate 3 Protein Insulin Receptor Substrate-3 |
We want your feedback on the new DeCS / MeSH website
We invite you to complete a survey that will take no more than 3 minutes.
Go to survey
