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Descriptor English: Signaling Lymphocytic Activation Molecule Associated Protein
Descriptor Spanish: Proteína Asociada a la Molécula de Señalización de la Activación Linfocitaria
Descriptor proteína asociada a la molécula de señalización de la activación linfocitaria
Entry term(s) proteína SH2D1A
proteína asociada a SLAM
Scope note: Proteína adaptadora de la señalización que contiene un único DOMINIO SH2 y que es esencial para la regulación de la FAMILIA DE RECEPTORES SLAM en la repuesta inmunitaria. Se han identificado mutaciones en el gen de la proteína asociada a SLAM en casos de SÍNDROME LINFOPROLIFERATIVO LIGADO AL CROMOSOMA X.
Descriptor Portuguese: Proteína Associada à Molécula de Sinalização da Ativação Linfocitária
Descriptor French: Protéine associée aux molécules de signalisation de l'activation des lymphocytes
Entry term(s): SH2D1A Protein
SLAM Associated Protein
SLAM-Associated Protein
Tree number(s): D12.644.360.024.332
D12.776.157.057.166
D12.776.476.024.426
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071179
Scope note: A signal transducing adaptor protein that contains a single SH2 DOMAIN and is essential for the regulation of SLAM FAMILY RECEPTORS in the immune response. Mutations in the SLAM-associated protein gene have been identified in cases of X-LINKED LYMPHOPROLIFERATIVE DISEASE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Carrier Proteins (1998-2016)
Intracellular Signaling Peptides and Proteins (2005-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56542
Unique ID: D000071179
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/26
Signaling Lymphocytic Activation Molecule Associated Protein - Preferred
Concept UI M000613389
Scope note A signal transducing adaptor protein that contains a single SH2 DOMAIN and is essential for the regulation of SLAM FAMILY RECEPTORS in the immune response. Mutations in the SLAM-associated protein gene have been identified in cases of X-LINKED LYMPHOPROLIFERATIVE DISEASE.
Preferred term Signaling Lymphocytic Activation Molecule Associated Protein
Entry term(s) SH2D1A Protein
SLAM Associated Protein
SLAM-Associated Protein



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