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Descriptor English: Kelch-Like ECH-Associated Protein 1
Descriptor Spanish: Proteína 1 Asociada A ECH Tipo Kelch
Descriptor Portuguese: Proteína 1 Associada a ECH Semelhante a Kelch
Descriptor French: Protéine-1 de type kelch associée à ECH
Entry term(s): KEAP 1 Protein
KEAP-1 Protein
KEAP1 Protein
Kelch Like ECH Associated Protein 1
Tree number(s): D12.644.360.024.306
D12.776.157.057.067
D12.776.476.024.387
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072019
Scope note: An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Adaptor Proteins, Signal Transducing (2005-2016)
Carrier Proteins (1999-2016)
Intracellular Signaling Peptides and Proteins (2004-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56536
Unique ID: D000072019
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/27
Kelch-Like ECH-Associated Protein 1 - Preferred
Concept UI M000616243
Scope note An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.
Preferred term Kelch-Like ECH-Associated Protein 1
Entry term(s) KEAP 1 Protein
KEAP-1 Protein
KEAP1 Protein
Kelch Like ECH Associated Protein 1



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