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Descriptor English: Amyloid
Descriptor Spanish: Amiloide
Descriptor amiloide
Entry term(s) fibrilla de amiloide
fibrillas de amiloide
Scope note: Tipo de sustancia que se deposita extracelularmente y está compuesta por una proteína amiloide y otros componentes, como PROTEOGLICANO DE HEPARÁN SULFATO, LAMININA, COLÁGENO TIPO IV, COMPONENTE SÉRICO P DEL AMILOIDE y APOLIPOPROTEÍNAS E, que juntos forman fibrillas amiloides características. El núcleo de las fibrillas amiloides está formado por dominios de hojas plegadas beta superpuestas de la proteína amiloide. Se han encontrado muchas proteínas amiloides diferentes que forman in vivo el núcleo de las fibrillas. Sin embargo, el amiloide puede formarse a partir de cualquier proteína que presente hojas plegadas beta durante el desplegamiento o el replegamiento. Una caracteristica común del amiloide es la capacidad de teñirse con colorantes como el ROJO CONGO y la tioflavina.
Descriptor Portuguese: Amiloide
Descriptor French: Amyloïde
Entry term(s): Amyloid Fibril
Amyloid Fibrils
Amyloid Substance
Fibril, Amyloid
Fibrils, Amyloid
Substance, Amyloid
Tree number(s): D05.500.049
D12.776.049
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000682
Scope note: A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.
Annotation: PLAQUE, AMYLOID is also available
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 68; was AMYLOID SUBSTANCE 1963-67
Online Note: use AMYLOID to search AMYLOID SUBSTANCE 1966-67 (as Cat C heading)
History Note: 68; was AMYLOID SUBSTANCE 1963-67 (Cat C heading only 1966-67, Cat A heading only 1963-64)
Related: Amyloidosis MeSH
DeCS ID: 696
Unique ID: D000682
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1968/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27
Amyloid - Preferred
Concept UI M0001047
Scope note A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.
Preferred term Amyloid
Entry term(s) Amyloid Substance
Substance, Amyloid
Amyloid Fibrils - Narrower
Concept UI M0455694
Preferred term Amyloid Fibrils
Entry term(s) Amyloid Fibril
Fibril, Amyloid
Fibrils, Amyloid



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