| Descriptor English: | GRB2 Adaptor Protein | ||||||
| Descriptor Spanish: |
Proteína Adaptadora GRB2
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| Descriptor Portuguese: | Proteína Adaptadora GRB2 | ||||||
| Descriptor French: | Protéine adaptatrice GRB2 | ||||||
| Entry term(s): |
Abundant Src Homology Protein GRB2 Adaptor Protein, Grb3 3 Isoform GRB2 Adaptor Protein, Grb3-3 Isoform Grb3-3 Adaptor Protein Growth Factor Receptor Bound Protein 2 Growth Factor Receptor-Bound Protein-2 |
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| Tree number(s): |
D12.644.360.024.290 D12.776.157.057.041 D12.776.476.024.377 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D051380 | ||||||
| Scope note: | A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS). |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Public MeSH Note: | 2006; GROWTH FACTOR RECEPTOR-BOUND PROTEIN-2 was indexed under ADAPTOR PROTEINS, SIGNAL TRANSDUCING 2005, & under PROTEINS 1992-2004 |
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| History Note: | 2006(1992) |
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| DeCS ID: | 50766 | ||||||
| Unique ID: | D051380 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2006/01/01 | ||||||
| Date of Entry: | 2005/06/30 | ||||||
| Revision Date: | 2017/05/24 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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GRB2 Adaptor Protein
- Preferred
GRB2 Adaptor Protein, Grb3-3 Isoform
- Narrower
| Concept UI |
M0204531 |
| Scope note | A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS). |
| Preferred term | GRB2 Adaptor Protein |
| Entry term(s) |
Abundant Src Homology Protein Growth Factor Receptor Bound Protein 2 Growth Factor Receptor-Bound Protein-2 |
| Concept UI |
M0204529 |
| Scope note | Grb3-3 is a natural isoform of GRB2 PROTEIN with a deletion in the SH2 DOMAIN. It acts as a dominant negative protein over GRB2, suppressing proliferative signals. It has also been implicated in APOPTOSIS. |
| Preferred term | GRB2 Adaptor Protein, Grb3-3 Isoform |
| Entry term(s) |
GRB2 Adaptor Protein, Grb3 3 Isoform Grb3-3 Adaptor Protein |
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