| Descriptor English: | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) | ||||||
| Descriptor Spanish: |
Proteína Tirosina Quinasa p56(lck) Específica de Linfocito
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| Descriptor Portuguese: | Proteína Tirosina Quinase p56(lck) Linfócito-Específica | ||||||
| Descriptor French: | Protéine tyrosine kinase p56(lck) spécifique des lymphocytes | ||||||
| Entry term(s): |
Kinase, lck Protein Tyrosine Kinase p56(lck) Protein c-lck, Proto-Oncogene Protein lck, Proto-Oncogene Proto Oncogene Protein c lck Proto Oncogene Protein lck Proto-Oncogene Protein c-lck Proto-Oncogene Protein lck c-lck, Proto-Oncogene Protein lck Kinase lck, Proto-Oncogene Protein p56 lck |
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| Tree number(s): |
D08.811.913.696.620.682.725.800.315 D12.776.476.568.800.315 D12.776.624.664.700.128 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019860 | ||||||
| Scope note: | This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.10.2 | ||||||
| Previous Indexing: |
Protein-Tyrosine Kinase (1988-1995) src-Family Kinases (1996-1997) |
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| Public MeSH Note: | 98; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK) was indexed under SRC-FAMILY KINASES 1996-97 & PROTEIN-TYROSINE KINASE 1988-95 |
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| History Note: | 98; use LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK) (NM) 1988-97 |
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| DeCS ID: | 33475 | ||||||
| Unique ID: | D019860 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1998/01/01 | ||||||
| Date of Entry: | 1997/07/02 | ||||||
| Revision Date: | 2009/07/06 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Preferred
| Concept UI |
M0029483 |
| Scope note | This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation. |
| Preferred term | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) |
| Entry term(s) |
Kinase, lck Protein Tyrosine Kinase p56(lck) Protein c-lck, Proto-Oncogene Protein lck, Proto-Oncogene Proto Oncogene Protein c lck Proto Oncogene Protein lck Proto-Oncogene Protein c-lck Proto-Oncogene Protein lck c-lck, Proto-Oncogene Protein lck Kinase lck, Proto-Oncogene Protein p56 lck |
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