| Descriptor English: | RNA-Binding Protein FUS | ||||
| Descriptor Spanish: |
Proteína FUS de Unión a ARN
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| Descriptor Portuguese: | Proteína FUS de Ligação a RNA | ||||
| Descriptor French: | Protéine FUS de liaison à l'ARN | ||||
| Entry term(s): |
FUS Protein FUS RNA Binding Protein FUS RNA-Binding Protein Fusion Protein in Myxoid Liposarcoma POMp75 Protein RNA Binding Protein FUS RNA-Binding Protein, FUS TLS Protein Translocated in Liposarcoma Protein hnRNP P2 |
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| Tree number(s): |
D12.776.157.725.500.313.905 D12.776.157.725.813.750.905 D12.776.624.664.700.915 D12.776.664.962.500.313.902 D12.776.664.962.813.750.902 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D034702 | ||||
| Scope note: | A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Ribonucleoproteins (1996-2002) |
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| Public MeSH Note: | 2003; FUS PROTEIN & HNRNP P2 were indexed under RIBONUCLEOPROTEINS 1996-2002; TLS PROTEIN was indexed under 1993-2002 RIBONUCLEOPROTEINS |
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| History Note: | 2003; for FUS PROTEIN & HNRNP P2 use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1996-2002; for TLS PROTEIN use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1993-2002; |
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| DeCS ID: | 37420 | ||||
| Unique ID: | D034702 | ||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||
| Date Established: | 2003/01/01 | ||||
| Date of Entry: | 2002/07/03 | ||||
| Revision Date: | 2015/04/15 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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RNA-Binding Protein FUS
- Preferred
| Concept UI |
M0087111 |
| Scope note | A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia. |
| Preferred term | RNA-Binding Protein FUS |
| Entry term(s) |
FUS Protein FUS RNA Binding Protein FUS RNA-Binding Protein Fusion Protein in Myxoid Liposarcoma POMp75 Protein RNA Binding Protein FUS RNA-Binding Protein, FUS TLS Protein Translocated in Liposarcoma Protein hnRNP P2 |
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