DeCS

Descriptor English:

RUNX1 Translocation Partner 1 Protein

Descriptor Spanish:

Proteína 1 Compañera de Translocación de RUNX1

Spanish from Spain

Descriptor	proteína 1 compañera de translocación de RUNX1
Entry term(s)	proteína Ocho Veintiuno proteína RUNX1 translocation partner 1 proteína RUNX1T1
Scope note:	Correpresor transcripcional que contiene un dedo de zinc de tipo MYND (DOMINIO MYND) en el extremo C-terminal y funciona como homooligómero. Se asocia a factores de transcripción de unión a ADN, a otras proteínas represoras y a HISTONA ACETILTRANSFERASAS para reprimir la expresión de genes implicados en el crecimiento y la diferenciación celular como la METALOPROTEINASA 7 DE LA MATRIZ y el factor de transcripción TCF12. En las células de pacientes con leucemia suele producirse una TRANSLOCACIÓN CROMOSÓMICA que afecta a los genes RUNX1T1 y la SUBUNIDAD ALFA 2 DEL FACTOR DE UNIÓN AL SITIO PRINCIPAL (RUNX1). La proteína de fusión resultante (AML1-ETO o RUNX1-RUNX1T1) juega un papel esencial en la leucemogénesis.

Descriptor Portuguese:

Proteína 1 Parceira de Translocação de RUNX1

Descriptor French:

Protéine-1 partenaire de translocation de RUNX1

Entry term(s):

Eight Twenty One Protein
RUNX1T1 Protein

Tree number(s):

D12.776.624.664.700.936
D12.776.930.780.625.575

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D000075142

Scope note:

A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Concept UI	M000629597
Scope note	A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.
Preferred term	RUNX1 Translocation Partner 1 Protein
Entry term(s)	Eight Twenty One Protein RUNX1T1 Protein

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