| Descriptor English: | Activin Receptors | ||||||
| Descriptor Spanish: |
Receptores de Activinas
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| Descriptor Portuguese: | Receptores de Ativinas | ||||||
| Descriptor French: | Récepteur activine | ||||||
| Entry term(s): |
Activin Receptor Activin Receptor like Kinase Activin Receptor like Kinases Activin Receptor-Like Kinases Activin Receptor-like Kinase Kinase, Activin Receptor-like Kinases, Activin Receptor-like Receptor, Activin Receptor-like Kinase, Activin Receptor-like Kinases, Activin |
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| Tree number(s): |
D08.811.913.696.620.682.700.062 D12.776.476.563.062 D12.776.543.750.750.400.820.500 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D029404 | ||||||
| Scope note: | Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.11.30 | ||||||
| Previous Indexing: |
Protein-Serine-Threonine Kinases (1993-2001) Receptors, Cell Surface (1989-1992) |
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| Public MeSH Note: | 2002; ACTIVIN RECEPTORS was indexed under RECEPTORS, GROWTH FACTOR |
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| History Note: | 2002; use ACTIVIN RECEPTORS (NM) 1991-2001 |
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| Entry Version: | ACTIVIN RECEPT |
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| DeCS ID: | 36116 | ||||||
| Unique ID: | D029404 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2002/01/01 | ||||||
| Date of Entry: | 2001/07/25 | ||||||
| Revision Date: | 2009/07/06 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Activin Receptors
- Preferred
| Concept UI |
M0229093 |
| Scope note | Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity. |
| Preferred term | Activin Receptors |
| Entry term(s) |
Activin Receptor Activin Receptor like Kinase Activin Receptor like Kinases Activin Receptor-Like Kinases Activin Receptor-like Kinase Kinase, Activin Receptor-like Kinases, Activin Receptor-like Receptor, Activin Receptor-like Kinase, Activin Receptor-like Kinases, Activin |
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