| Descriptor English: | Checkpoint Kinase 1 | ||||||
| Descriptor Spanish: |
Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1)
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| Descriptor Portuguese: | Quinase 1 do Ponto de Checagem | ||||||
| Descriptor French: | Checkpoint kinase 1 | ||||||
| Entry term(s): |
Checkpoint-1 Kinase Chk1 Kinase Chk1 Protein Kinase Protein Kinase, Chk1 |
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| Tree number(s): |
D08.811.913.696.620.682.700.143 D12.776.476.563.143 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071877 | ||||||
| Scope note: | A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.11.1 | ||||||
| Public MeSH Note: | 2017; CHECKPOINT KINASE 1 was indexed under PROTEIN KINASES 2004-2016 |
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| History Note: | 2017 (2004) |
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| DeCS ID: | 56510 | ||||||
| Unique ID: | D000071877 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2016/05/26 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Checkpoint Kinase 1
- Preferred
| Concept UI |
M0217020 |
| Scope note | A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle. |
| Preferred term | Checkpoint Kinase 1 |
| Entry term(s) |
Checkpoint-1 Kinase Chk1 Kinase Chk1 Protein Kinase Protein Kinase, Chk1 |
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