| Descriptor English: | rho-Associated Kinases | ||||||
| Descriptor Spanish: |
Quinasas Asociadas a rho
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| Descriptor Portuguese: | Quinases Associadas a rho | ||||||
| Descriptor French: | rho-Associated Kinases | ||||||
| Entry term(s): |
Coiled-Coil Kinase, rho-Associated Protein Kinases, ROCK ROCK I Protein Kinase ROCK II Protein Kinase ROCK Protein Kinases ROCK-I Protein Kinase ROCK-II Protein Kinase ROK Kinase p160 rhoA Binding Kinase ROKalpha p160 rhoA-Binding Kinase ROKalpha p160ROCK rho Associated Coiled Coil Containing Protein Kinase 1 rho Associated Coiled Coil Containing Protein Kinase 2 rho Associated Coiled Coil Kinase rho Associated Kinase rho Associated Kinase 1 rho Associated Kinase 2 rho Associated Kinase alpha rho Associated Kinase beta rho Associated Kinases rho Associated Protein Kinase alpha rho Associated Protein Kinase beta rho Kinase rho-Associated Coiled-Coil Containing Protein Kinase 1 rho-Associated Coiled-Coil Containing Protein Kinase 2 rho-Associated Coiled-Coil Kinase rho-Associated Kinase rho-Associated Kinase 1 rho-Associated Kinase 2 rho-Associated Kinase alpha rho-Associated Kinase beta rho-Associated Protein Kinase alpha rho-Associated Protein Kinase beta rho-Kinase |
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| Tree number(s): |
D08.811.913.696.620.682.700.814 D12.776.476.563.814 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D054460 | ||||||
| Scope note: | A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.11.1 | ||||||
| Public MeSH Note: | 2008; RHO-ASSOCIATED KINASES was indexed under PROTEIN-SERINE-THREONINE KINASES & INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS 1996-2007 |
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| History Note: | 2008 |
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| DeCS ID: | 52746 | ||||||
| Unique ID: | D054460 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2008/01/01 | ||||||
| Date of Entry: | 2007/07/09 | ||||||
| Revision Date: | 2015/11/24 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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rho-Associated Kinases
- Preferred
rho-Associated Kinase 1
- Narrower
rho-Associated Kinase 2
- Narrower
| Concept UI |
M0261519 |
| Scope note | A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES. |
| Preferred term | rho-Associated Kinases |
| Entry term(s) |
Coiled-Coil Kinase, rho-Associated Protein Kinases, ROCK ROCK Protein Kinases ROK Kinase rho Associated Coiled Coil Kinase rho Associated Kinase rho Associated Kinases rho Kinase rho-Associated Coiled-Coil Kinase rho-Associated Kinase rho-Kinase |
| Concept UI |
M0261509 |
| Preferred term | rho-Associated Kinase 1 |
| Entry term(s) |
ROCK I Protein Kinase ROCK-I Protein Kinase p160ROCK rho Associated Coiled Coil Containing Protein Kinase 1 rho Associated Kinase 1 rho Associated Kinase beta rho Associated Protein Kinase beta rho-Associated Coiled-Coil Containing Protein Kinase 1 rho-Associated Kinase beta rho-Associated Protein Kinase beta |
| Concept UI |
M0261510 |
| Preferred term | rho-Associated Kinase 2 |
| Entry term(s) |
ROCK II Protein Kinase ROCK-II Protein Kinase p160 rhoA Binding Kinase ROKalpha p160 rhoA-Binding Kinase ROKalpha rho Associated Coiled Coil Containing Protein Kinase 2 rho Associated Kinase 2 rho Associated Kinase alpha rho Associated Protein Kinase alpha rho-Associated Coiled-Coil Containing Protein Kinase 2 rho-Associated Kinase alpha rho-Associated Protein Kinase alpha |
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