| Descriptor English: | p21-Activated Kinases | ||||||
| Descriptor Spanish: |
Quinasas p21 Activadas
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| Descriptor Portuguese: | Quinases Ativadas por p21 | ||||||
| Descriptor French: | p21-Activated Kinases | ||||||
| Entry term(s): |
Kinase, PAK Kinase, p21-Activated Kinases, PAK Kinases, p21-Activated Oligophrenin 3 Oligophrenin-3 PAK 1 Kinase PAK 2 Kinase PAK Kinase PAK Kinases PAK-1 Kinase PAK-2 Kinase PAK1 Kinase PAK2 Kinase PAK3 Kinase PAK65 Serine Threonine Protein Kinase PAK 1 Serine Threonine Protein Kinase PAK 3 Serine-Threonine-Protein Kinase PAK 1 Serine-Threonine-Protein Kinase PAK 3 alpha p21 Activated Kinase alpha p21-Activated Kinase alpha-PAK beta p21 Activated Kinase beta p21-Activated Kinase beta-PAK gamma PAK gamma-PAK p21 Activated Kinase p21 Activated Kinase 1 p21 Activated Kinase 2 p21 Activated Kinase 3 p21 Activated Kinases p21-Activated Kinase p21-Activated Kinase 1 p21-Activated Kinase 2 p21-Activated Kinase 3 p21-Activated Kinase, beta p65(PAK) p65PAK Protein |
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| Tree number(s): |
D08.811.913.696.620.682.700.596 D12.776.476.563.596 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D054462 | ||||||
| Scope note: | A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.11.1 | ||||||
| Previous Indexing: |
Protein-Serine-Threonine Kinases (1995-2007) |
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| Public MeSH Note: | 2008; P21-ACTIVATED KINASE 1, P21-ACTIVATED KINASE 2 & P21-ACTIVATED KINASE 3 were indexed under PROTEIN-SERINE-THREONINE KINASES 1995-2007 |
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| History Note: | 2008 |
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| DeCS ID: | 52745 | ||||||
| Unique ID: | D054462 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2008/01/01 | ||||||
| Date of Entry: | 2007/07/09 | ||||||
| Revision Date: | 2020/05/27 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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p21-Activated Kinases
- Preferred
p21-Activated Kinase 2
- Narrower
p21-Activated Kinase 1
- Narrower
p21-Activated Kinase 3
- Narrower
| Concept UI |
M0505237 |
| Scope note | A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization. |
| Preferred term | p21-Activated Kinases |
| Entry term(s) |
Kinase, PAK Kinase, p21-Activated Kinases, PAK Kinases, p21-Activated PAK Kinase PAK Kinases p21 Activated Kinase p21 Activated Kinases p21-Activated Kinase |
| Concept UI |
M0249380 |
| Preferred term | p21-Activated Kinase 2 |
| Entry term(s) |
PAK 2 Kinase PAK-2 Kinase PAK2 Kinase PAK65 gamma PAK gamma-PAK p21 Activated Kinase 2 p65(PAK) p65PAK Protein |
| Concept UI |
M0249429 |
| Preferred term | p21-Activated Kinase 1 |
| Entry term(s) |
PAK 1 Kinase PAK-1 Kinase PAK1 Kinase Serine Threonine Protein Kinase PAK 1 Serine-Threonine-Protein Kinase PAK 1 alpha p21 Activated Kinase alpha p21-Activated Kinase alpha-PAK p21 Activated Kinase 1 |
| Concept UI |
M0252435 |
| Preferred term | p21-Activated Kinase 3 |
| Entry term(s) |
Oligophrenin 3 Oligophrenin-3 PAK3 Kinase Serine Threonine Protein Kinase PAK 3 Serine-Threonine-Protein Kinase PAK 3 beta p21 Activated Kinase beta p21-Activated Kinase beta-PAK p21 Activated Kinase 3 p21-Activated Kinase, beta |
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