| Descriptor English: | eIF-2 Kinase | ||||||
| Descriptor Spanish: |
eIF-2 Quinasa
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| Descriptor Portuguese: | eIF-2 Quinase | ||||||
| Descriptor French: | eIF-2 Kinase | ||||||
| Entry term(s): |
Controlled Repressor, Heme Controlled Repressor, Hemin DAI Protein Kinase DSRNA Dep Protein Kinase DSRNA-Dep Protein Kinase Double Stranded RNA Dependent eIF 2 alpha Protein Kinase Double Stranded RNA-Dependent Kinase (dsl) Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase Eukaryotic Initiation Factor 2alpha Kinase Heme Controlled Inhibitor Heme Controlled Repressor Heme Controlled Translational Repressor Heme Regulated eIF 2alpha Kinase Heme-Controlled Inhibitor Heme-Controlled Translational Repressor Heme-Regulated eIF-2alpha Kinase Hemin Controlled Repressor Hemin Controlled Translational Repressor Hemin-Controlled Translational Repressor Inhibitor, Heme-Controlled Inhibitor, dsRNA-Activated Kinase PKR, Protein Kinase, DAI Protein Kinase, DSRNA-Dep Protein Kinase, Heme-Regulated eIF-2alpha Kinase, P68 Protein Kinase, RNA-Dependent Protein Kinase, Self-Phosphorylating Protein Kinase, TIK Kinase, eIF-2 Kinase, eIF-2alpha Kinase, p65 Kinase, p68 P68 Protein Kinase PKR, Protein Kinase Protein Kinase PKR Protein Kinase, DAI Protein Kinase, DSRNA-Dep Protein Kinase, P68 Protein Kinase, RNA Activated Protein Kinase, RNA-Dependent Protein Kinase, Self-Phosphorylating RNA Dependent Protein Kinase RNA-Dependent Protein Kinase Repressor, Heme Controlled Repressor, Heme-Controlled Translational Repressor, Hemin Controlled Repressor, Hemin-Controlled Translational Self Phosphorylating Protein Kinase Self-Phosphorylating Protein Kinase TIK Kinase Translational Repressor, Heme-Controlled Translational Repressor, Hemin-Controlled dsRNA Activated Inhibitor dsRNA-Activated Inhibitor eIF 2 Kinase eIF 2alpha Kinase eIF-2alpha Kinase eIF-2alpha Kinase, Heme-Regulated eRF, eIF 2 Recycling Factor eRF, eIF-2 Recycling Factor p65 Kinase p68 Kinase |
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| Tree number(s): |
D08.811.913.696.620.682.700.300 D12.776.476.563.300 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019892 | ||||||
| Scope note: | A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.11.1 | ||||||
| Previous Indexing: |
Protein Kinases (1980-1993) Protein-Serine-Threonine Kinases (1993-1997) |
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| Public MeSH Note: | 98; EIF-2 KINASE was indexed under PROTEIN-SERINE-THREONINE KINASES 1993-97 & PROTEIN KINASES 1980-93 |
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| History Note: | 98; use EIF-2 KINASE (NM) 1980-97 |
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| DeCS ID: | 33472 | ||||||
| Unique ID: | D019892 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1998/01/01 | ||||||
| Date of Entry: | 1997/07/02 | ||||||
| Revision Date: | 2015/11/23 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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eIF-2 Kinase
- Preferred
| Concept UI |
M0029534 |
| Scope note | A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis. |
| Preferred term | eIF-2 Kinase |
| Entry term(s) |
Controlled Repressor, Heme Controlled Repressor, Hemin DAI Protein Kinase DSRNA Dep Protein Kinase DSRNA-Dep Protein Kinase Double Stranded RNA Dependent eIF 2 alpha Protein Kinase Double Stranded RNA-Dependent Kinase (dsl) Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase Eukaryotic Initiation Factor 2alpha Kinase Heme Controlled Inhibitor Heme Controlled Repressor Heme Controlled Translational Repressor Heme Regulated eIF 2alpha Kinase Heme-Controlled Inhibitor Heme-Controlled Translational Repressor Heme-Regulated eIF-2alpha Kinase Hemin Controlled Repressor Hemin Controlled Translational Repressor Hemin-Controlled Translational Repressor Inhibitor, Heme-Controlled Inhibitor, dsRNA-Activated Kinase PKR, Protein Kinase, DAI Protein Kinase, DSRNA-Dep Protein Kinase, Heme-Regulated eIF-2alpha Kinase, P68 Protein Kinase, RNA-Dependent Protein Kinase, Self-Phosphorylating Protein Kinase, TIK Kinase, eIF-2 Kinase, eIF-2alpha Kinase, p65 Kinase, p68 P68 Protein Kinase PKR, Protein Kinase Protein Kinase PKR Protein Kinase, DAI Protein Kinase, DSRNA-Dep Protein Kinase, P68 Protein Kinase, RNA Activated Protein Kinase, RNA-Dependent Protein Kinase, Self-Phosphorylating RNA Dependent Protein Kinase RNA-Dependent Protein Kinase Repressor, Heme Controlled Repressor, Heme-Controlled Translational Repressor, Hemin Controlled Repressor, Hemin-Controlled Translational Self Phosphorylating Protein Kinase Self-Phosphorylating Protein Kinase TIK Kinase Translational Repressor, Heme-Controlled Translational Repressor, Hemin-Controlled dsRNA Activated Inhibitor dsRNA-Activated Inhibitor eIF 2 Kinase eIF 2alpha Kinase eIF-2alpha Kinase eIF-2alpha Kinase, Heme-Regulated eRF, eIF 2 Recycling Factor eRF, eIF-2 Recycling Factor p65 Kinase p68 Kinase |
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