DeCS

Descriptor English:

Receptor, Transforming Growth Factor-beta Type II

Descriptor Spanish:

Receptor Tipo II de Factor de Crecimiento Transformador beta

Spanish from Spain

Descriptor	receptor de tipo II del factor de crecimiento transformante beta
Entry term(s)	TGFBR2 cinasa TbetaR II cinasa TbetaR-II receptores de tipo II del factor de crecimiento transformante beta receptores de tipo II del factor de crecimiento transformante-beta
Scope note:	Serina-treonina-cinasa transmembranaria que forma un complejo heteromérico con el RECEPTOR DE TIPO I DEL FACTOR DE CRECIMIENTO TRANSFORMANTE BETA al unirse al TGF-BETA. Este complejo receptor regula diversos procesos fisiológicos y patológicos tales como la detención del ciclo celular, la PROLIFERACIÓN CELULAR, la DIFERENCIACIÓN CELULAR, la CICATRIZACIÓN DE HERIDAS, la producción de MATRIZ EXTRACELULAR, la inmunosupresión y la ONCOGÉNESIS.

Descriptor Portuguese:

Receptor do Fator de Crescimento Transformador beta Tipo II

Descriptor French:

Récepteur de type II du facteur de croissance transformant bêta

Entry term(s):

Kinase, TbetaR-II
Receptor, Transforming Growth Factor beta Type II
TGF beta Type II Receptor
TGF beta Type II Receptors
TGF-beta Type II Receptor
TGF-beta Type II Receptors
TGFBR2
TbetaR II Kinase
TbetaR-II Kinase
Transforming Growth Factor beta Type II Receptor
Transforming Growth Factor beta Type II Receptors
Transforming Growth Factor-beta Type II Receptor
Transforming Growth Factor-beta Type II Receptors
Type II TGF beta Receptor
Type II TGF beta Receptors
Type II TGF-beta Receptor
Type II TGF-beta Receptors

Tree number(s):

D08.811.913.696.620.682.700.795
D12.776.476.563.795
D12.776.543.750.705.852.720.750
D12.776.543.750.750.400.820.875

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D000077294

Scope note:

A transmembrane serine-threonine kinase that forms a heteromeric complex with TYPE I TGF-BETA RECEPTORS when bound to TGF-BETA. This receptor complex regulates a variety of physiological and pathological processes including CELL CYCLE ARREST; CELL PROLIFERATION; CELL DIFFERENTIATION; WOUND HEALING; EXTRACELLULAR MATRIX production, immunosuppression and ONCOGENESIS.

Allowable Qualifiers:

AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure

Registry Number:

EC 2.7.11.30

Public MeSH Note:

2019; see TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR 1993-2018; RECEPTOR, TRANSFORMING GROWTH FACTOR-BETA TYPE II was indexed under PROTEIN-SERINE-THREONINE KINASES and RECEPTORS, TRANSFORMING GROWTH FACTOR BETA 1994-2018; and under RECEPTORS, ENDOGENOUS SUBSTANCES 1993

Concept UI	M0215077
Scope note	A transmembrane serine-threonine kinase that forms a heteromeric complex with TYPE I TGF-BETA RECEPTORS when bound to TGF-BETA. This receptor complex regulates a variety of physiological and pathological processes including CELL CYCLE ARREST; CELL PROLIFERATION; CELL DIFFERENTIATION; WOUND HEALING; EXTRACELLULAR MATRIX production, immunosuppression and ONCOGENESIS.
Preferred term	Receptor, Transforming Growth Factor-beta Type II
Entry term(s)	Kinase, TbetaR-II Receptor, Transforming Growth Factor beta Type II TGF beta Type II Receptor TGF beta Type II Receptors TGF-beta Type II Receptor TGF-beta Type II Receptors TGFBR2 TbetaR II Kinase TbetaR-II Kinase Transforming Growth Factor beta Type II Receptor Transforming Growth Factor beta Type II Receptors Transforming Growth Factor-beta Type II Receptor Transforming Growth Factor-beta Type II Receptors Type II TGF beta Receptor Type II TGF beta Receptors Type II TGF-beta Receptor Type II TGF-beta Receptors

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