| Descriptor English: | WNK Lysine-Deficient Protein Kinase 1 | ||||||
| Descriptor Spanish: |
Proteína Quinasa Deficiente en Lisina WNK 1
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| Descriptor Portuguese: | Proteína Quinase 1 Deficiente de Lisina WNK | ||||||
| Descriptor French: | Protéine kinase déficiente en lysine WNK-1 | ||||||
| Entry term(s): |
WNK Lysine Deficient Protein Kinase 1 |
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| Tree number(s): |
D08.811.913.696.620.682.700.982 D12.776.476.563.982 D23.050.301.500.600.962 D23.050.705.552.600.925 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000076204 | ||||||
| Scope note: | A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.11.1 | ||||||
| Previous Indexing: |
Intracellular Signaling Peptides and Proteins (2005-2017) Minor Histocompatibility Antigens (2005-2017) Protein-Serine-Threonine Kinases (2005-2017) |
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| Public MeSH Note: | 2018 |
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| History Note: | 2018 |
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| DeCS ID: | 57033 | ||||||
| Unique ID: | D000076204 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/06/29 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors
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WNK Lysine-Deficient Protein Kinase 1
- Preferred
| Concept UI |
M000632439 |
| Scope note | A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES. |
| Preferred term | WNK Lysine-Deficient Protein Kinase 1 |
| Entry term(s) |
WNK Lysine Deficient Protein Kinase 1 |
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