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Descriptor English: Heterogeneous-Nuclear Ribonucleoprotein K
Descriptor Spanish: Ribonucleoproteína Heterogénea-Nuclear Grupo K
Descriptor ribonucleoproteína heterogénea nuclear K
Scope note: Ribonucleoproteína nuclear heterogénea que se encuentra en el NÚCLEO CELULAR y en el CITOPLASMA. Se ha implicado a la ribonucleoproteína nuclear heterogénea K en la regulación de la expresión genética en casi todos los niveles: TRANSCRIPCIÓN GENÉTICA, procesamiento del ARNm (PROCESAMIENTO DEL ARN POSTRANSCRIPCIONAL), transporte del ARNm, estabilidad del ARNm y traducción (TRADUCCIÓN GENÉTICA). La proteína hnRNP tiene una fuerte afinidad por el ARN rico en polipirimidina y por el ADN de hebra única rico en polipirimidina. Existen múltiples isoformas de la proteína K hnRNP debido a ayuste alternativo y muestran características diferentes en la unión al ácido nucleico.
Descriptor Portuguese: Ribonucleoproteínas Nucleares Heterogêneas Grupo K
Descriptor French: Ribonucléoprotéine nucléaire hétérogène K
Entry term(s): Heterogeneous Nuclear Ribonucleoprotein K
Heterogeneous Nuclear Ribonucleoprotein Particle K Protein
Ribonucleoprotein K, Heterogeneous-Nuclear
dC Stretch Binding Protein
dC-Stretch-Binding Protein
hnRNP K
hnRNP K Protein
Tree number(s): D12.776.157.725.813.750.500
D12.776.260.268
D12.776.664.962.813.750.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D034641
Scope note: A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.
Annotation: see SCR for specific hnRNP entries
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: DNA-Binding Proteins (1994-2002)
Ribonucleoproteins (1994-2002)
Public MeSH Note: 2003; DC-STRETCH-BINDING PROTEIN (now HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K) was indexed under DNA-BINDING PROTEINS 1994-2002; HNRNP K was indexed under RIBONUCLEOPROTEINS 1994-2002
History Note: 2003; use HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K (NM) 1994-2002; for HNRNP K use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1994-2002
DeCS ID: 37415
Unique ID: D034641
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2015/04/15
Heterogeneous-Nuclear Ribonucleoprotein K - Preferred
Concept UI M0087108
Scope note A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.
Preferred term Heterogeneous-Nuclear Ribonucleoprotein K
Entry term(s) Heterogeneous Nuclear Ribonucleoprotein K
Ribonucleoprotein K, Heterogeneous-Nuclear
hnRNP K
hnRNP K Protein - Narrower
Concept UI M0406273
Preferred term hnRNP K Protein
Entry term(s) Heterogeneous Nuclear Ribonucleoprotein Particle K Protein
dC Stretch Binding Protein
dC-Stretch-Binding Protein



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