| Descriptor English: | mTOR Associated Protein, LST8 Homolog | ||||||
| Descriptor Spanish: |
Homóloga LST8 de la Proteína Asociada al mTOR
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| Descriptor Portuguese: | Homólogo LST8 da Proteína Associada a mTOR | ||||||
| Descriptor French: | Protéine homologue de LST8 associée à MTOR | ||||||
| Entry term(s): |
G protein beta Subunit like Polypeptide G protein beta Subunit-like Polypeptide GBetaL Protein mLST8 Protein |
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| Tree number(s): |
D05.500.337.250 D08.811.913.696.620.682.700.931.500.250 D12.644.360.024.310 D12.776.157.057.073 D12.776.476.024.389 D12.776.476.563.931.500.250 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000076242 | ||||||
| Scope note: | An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and MTORC2 COMPLEX. It interacts directly with MTOR to enhance its kinase activity and stabilizes the MTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of MTOR activity. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Adaptor Proteins, Signal Transducing (2013-2017) Proteins (2011-2017) |
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| Public MeSH Note: | 2018 |
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| History Note: | 2018 |
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| DeCS ID: | 56983 | ||||||
| Unique ID: | D000076242 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/06/29 |
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CHEMICALS AND DRUGS
Macromolecular Substances [D05]Macromolecular Substances -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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mTOR Associated Protein, LST8 Homolog
- Preferred
| Concept UI |
M000632423 |
| Scope note | An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and MTORC2 COMPLEX. It interacts directly with MTOR to enhance its kinase activity and stabilizes the MTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of MTOR activity. |
| Preferred term | mTOR Associated Protein, LST8 Homolog |
| Entry term(s) |
G protein beta Subunit like Polypeptide G protein beta Subunit-like Polypeptide GBetaL Protein mLST8 Protein |
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