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Descriptor English: Sirtuins
Descriptor Spanish: Sirtuinas
Descriptor Portuguese: Sirtuínas
Descriptor French: Sirtuines
Entry term(s): SIRT
SIRTs
Silent Mating Type Information Regulator 2 like Proteins
Silent Mating Type Information Regulator 2-like Proteins
Sir2 like Proteins
Sir2-like Proteins
Sirtuin
Tree number(s): D08.811.277.087.520.200.650
D08.811.913.400.725.115.961
D12.776.476.900
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D037761
Scope note: A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.5.1.-
Previous Indexing: Histone Deacetylase (2000-2002)
Public MeSH Note: 2003
History Note: 2003
Related: Silent Information Regulator Proteins, Saccharomyces cerevisiae MeSH
DeCS ID: 37322
Unique ID: D037761
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2020/05/27
Sirtuins - Preferred
Concept UI M0413549
Scope note A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.
Preferred term Sirtuins
Entry term(s) SIRT
SIRTs
Silent Mating Type Information Regulator 2 like Proteins
Silent Mating Type Information Regulator 2-like Proteins
Sir2 like Proteins
Sir2-like Proteins
Sirtuin



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