| Descriptor English: | Sirtuins | ||||||
| Descriptor Spanish: |
Sirtuinas
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| Descriptor Portuguese: | Sirtuínas | ||||||
| Descriptor French: | Sirtuines | ||||||
| Entry term(s): |
SIRT SIRTs Silent Mating Type Information Regulator 2 like Proteins Silent Mating Type Information Regulator 2-like Proteins Sir2 like Proteins Sir2-like Proteins Sirtuin |
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| Tree number(s): |
D08.811.277.087.520.200.650 D08.811.913.400.725.115.961 D12.776.476.900 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D037761 | ||||||
| Scope note: | A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 3.5.1.- | ||||||
| Previous Indexing: |
Histone Deacetylase (2000-2002) |
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| Public MeSH Note: | 2003 |
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| History Note: | 2003 |
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| Related: |
Silent Information Regulator Proteins, Saccharomyces cerevisiae
MeSH | ||||||
| DeCS ID: | 37322 | ||||||
| Unique ID: | D037761 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2003/01/01 | ||||||
| Date of Entry: | 2002/07/03 | ||||||
| Revision Date: | 2020/05/27 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Sirtuins
- Preferred
| Concept UI |
M0413549 |
| Scope note | A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities. |
| Preferred term | Sirtuins |
| Entry term(s) |
SIRT SIRTs Silent Mating Type Information Regulator 2 like Proteins Silent Mating Type Information Regulator 2-like Proteins Sir2 like Proteins Sir2-like Proteins Sirtuin |
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