| Descriptor English: | Tumor Suppressor p53-Binding Protein 1 | ||||||
| Descriptor Spanish: |
Proteína 1 de Unión al Supresor Tumoral P53
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| Descriptor Portuguese: | Proteína 1 de Ligação à Proteína Supressora de Tumor p53 | ||||||
| Descriptor French: | Protéine-1 liant le suppresseur de tumeur p53 | ||||||
| Entry term(s): |
53BP1 Protein TP53BP1 Protein Tumor Protein p53 Binding Protein, 1 Tumor Protein p53-Binding Protein, 1 Tumor Suppressor p53 Binding Protein 1 p202 Protein |
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| Tree number(s): |
D12.776.260.805 D12.776.660.235.850 D12.776.664.235.950 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071857 | ||||||
| Scope note: | A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Chromosomal Proteins, Non-Histone (2005-2016) DNA-Binding Proteins (2005-2016) Intracellular Signaling Peptides and Proteins (2005-2016) |
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| Public MeSH Note: | 2017 |
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| History Note: | 2017 |
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| DeCS ID: | 56612 | ||||||
| Unique ID: | D000071857 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2016/07/05 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Tumor Suppressor p53-Binding Protein 1
- Preferred
| Concept UI |
M000615636 |
| Scope note | A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation. |
| Preferred term | Tumor Suppressor p53-Binding Protein 1 |
| Entry term(s) |
53BP1 Protein TP53BP1 Protein Tumor Protein p53 Binding Protein, 1 Tumor Protein p53-Binding Protein, 1 Tumor Suppressor p53 Binding Protein 1 p202 Protein |
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