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Descriptor English: Orphan Nuclear Receptors
Descriptor Spanish: Receptores Nucleares Huérfanos
Descriptor receptores nucleares huérfanos
Entry term(s) receptor nuclear huérfano
Scope note: Amplia categoría de proteínas similares a receptores que pueden desempeñar un papel en la regulación transcripcional del NÚCLEO CELULAR. Muchas de estas proteínas son similares en estructura a los conocidos RECEPTORES NUCELARES, pero parece que carecen de un dominio funcional de unión al ligando, mientras que en otros casos aún tienen que ser identificados los ligandos específicos.
Descriptor Portuguese: Receptores Nucleares Órfãos
Descriptor French: Récepteurs nucléaires orphelins
Entry term(s): Nuclear Receptor, Orphan
Nuclear Receptors, Orphan
Orphan Nuclear Receptor
Receptor, Orphan Nuclear
Receptors, Orphan Nuclear
Tree number(s): D12.776.260.643
D12.776.826.209
D12.776.930.645
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D057093
Scope note: A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.
Annotation: do not confuse with RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTORS
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2010
History Note: 2010
DeCS ID: 53643
Unique ID: D057093
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2020/05/27
Orphan Nuclear Receptors - Preferred
Concept UI M0534523
Scope note A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.
Preferred term Orphan Nuclear Receptors
Entry term(s) Nuclear Receptor, Orphan
Nuclear Receptors, Orphan
Orphan Nuclear Receptor
Receptor, Orphan Nuclear
Receptors, Orphan Nuclear



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