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Descriptor English: Ataxins
Descriptor Spanish: Ataxinas
Descriptor Portuguese: Ataxinas
Descriptor French: Ataxines
Entry term(s): Ataxia Protein, Spinocerebellar
Ataxia Proteins, Spinocerebellar
Ataxin
Ataxin Protein
Ataxin Proteins
Protein, Ataxin
Protein, Spinocerebellar Ataxia
Proteins, Ataxin
Proteins, Spinocerebellar Ataxia
Spinocerebellar Ataxia Protein
Spinocerebellar Ataxia Proteins
Tree number(s): D12.776.631.069
D12.776.660.075
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000067528
Scope note: A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. The expansion of CAG trinucleotide repeats in genes that encode Ataxins is associated with SPINOCEREBELLAR ATAXIAS (SCA). In SCA patients, the number of CAG repeats correlates with the severity of disease and inversely correlates with the age of disease onset.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Nerve Tissue Proteins (1995-2015)
Nuclear Proteins (1995-2015)
Public MeSH Note: 2016
History Note: 2016
Related: Spinocerebellar Ataxias MeSH
DeCS ID: 56001
Unique ID: D000067528
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2016/01/01
Date of Entry: 2015/07/06
Revision Date: 2020/05/27
Ataxins - Preferred
Concept UI M000599991
Scope note A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. The expansion of CAG trinucleotide repeats in genes that encode Ataxins is associated with SPINOCEREBELLAR ATAXIAS (SCA). In SCA patients, the number of CAG repeats correlates with the severity of disease and inversely correlates with the age of disease onset.
Preferred term Ataxins
Entry term(s) Ataxia Protein, Spinocerebellar
Ataxia Proteins, Spinocerebellar
Ataxin
Ataxin Protein
Ataxin Proteins
Protein, Ataxin
Protein, Spinocerebellar Ataxia
Proteins, Ataxin
Proteins, Spinocerebellar Ataxia
Spinocerebellar Ataxia Protein
Spinocerebellar Ataxia Proteins



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