| Descriptor English: | Ribosomal Protein S6 Kinases | ||||||
| Descriptor Spanish: |
Proteínas Quinasas S6 Ribosómicas
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| Descriptor Portuguese: | Proteínas Quinases S6 Ribossômicas | ||||||
| Descriptor French: | Ribosomal Protein S6 Kinases | ||||||
| Entry term(s): |
Ribosomal Protein S6 Kinase S6 H4 Kinase S6 Kinase S6-H4 Kinase |
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| Tree number(s): |
D08.811.913.696.620.682.700.862 D12.776.476.563.862 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019893 | ||||||
| Scope note: | A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.11.1 | ||||||
| Previous Indexing: |
Protein Kinases (1985-1992) Protein-Serine-Threonine Kinases (1993-1997) |
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| Public MeSH Note: | 2003; see RIBOSOMAL PROTEIN S6 KINASE 1998-2002; RIBOSOMAL PROTEIN S6 KINASE was indexed under PROTEIN-SERINE-THREONINE KINASES 1993-1997 & PROTEIN KINASES 1985-1992 |
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| History Note: | 2003(1998); use RIBOSOMAL PROTEIN S6 KINASES (NM) 1985-1997 |
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| Related: |
Coffin-Lowry Syndrome
MeSH Ribosomal Protein S6 MeSH | ||||||
| DeCS ID: | 33474 | ||||||
| Unique ID: | D019893 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1998/01/01 | ||||||
| Date of Entry: | 1997/06/20 | ||||||
| Revision Date: | 2015/11/24 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Ribosomal Protein S6 Kinases
- Preferred
| Concept UI |
M0029535 |
| Scope note | A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases. |
| Preferred term | Ribosomal Protein S6 Kinases |
| Entry term(s) |
Ribosomal Protein S6 Kinase S6 H4 Kinase S6 Kinase S6-H4 Kinase |
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