| Descriptor English: | AIRE Protein | ||||||
| Descriptor Spanish: |
Proteína AIRE
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| Descriptor Portuguese: | Proteína AIRE | ||||||
| Descriptor French: | Without translation | ||||||
| Entry term(s): |
APECED Protein Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein Autoimmune Regulator Protein Protein, AIRE Protein, APECED Protein, Autoimmune Regulator Regulator Protein, Autoimmune |
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| Tree number(s): |
D12.776.930.123 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000096927 | ||||||
| Scope note: | A transcriptional regulator primarily expressed in medullary thymic epithelial cells. It plays an important role in immunity by regulating the expression of a wide array of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Public MeSH Note: | 2024; AIRE PROTEIN was indexed under TRANSCRIPTION FACTORS 1997-2023 |
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| History Note: | 2024 (1997) |
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| DeCS ID: | 60533 | ||||||
| Unique ID: | D000096927 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2024/01/01 | ||||||
| Date of Entry: | 2023/07/26 | ||||||
| Revision Date: | 2023/05/16 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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AIRE Protein
- Preferred
| Concept UI |
M000762772 |
| Scope note | A transcriptional regulator primarily expressed in medullary thymic epithelial cells. It plays an important role in immunity by regulating the expression of a wide array of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY. |
| Preferred term | AIRE Protein |
| Entry term(s) |
APECED Protein Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein Autoimmune Regulator Protein Protein, AIRE Protein, APECED Protein, Autoimmune Regulator Regulator Protein, Autoimmune |
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