| Descriptor English: | NFATC Transcription Factors | ||||||
| Descriptor Spanish: |
Factores de Transcripción NFATC
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| Descriptor Portuguese: | Fatores de Transcrição NFATC | ||||||
| Descriptor French: | Facteurs de transcription NFATC | ||||||
| Entry term(s): |
Factor, NFATC1 Transcription Factor, NFATC2 Transcription Factor, NFATC3 Transcription NF AT Proteins NF AT3 Protein NF AT4 Protein NF ATc1 Protein NF-AT Proteins NF-AT, Transcription Factor NF-AT3 Protein NF-AT4 Protein NF-ATc1 Protein NFAT 1 Protein NFAT 2 Protein NFAT Proteins NFAT Transcription Factor 1 NFAT Transcription Factor 2 NFAT Transcription Factor 3 NFAT Transcription Factor 4 NFAT Transcription Factor 5 NFAT-1 Protein NFAT-2 Protein NFAT1 Protein NFAT2 Protein NFAT3 Protein NFAT4 Protein NFAT5 Protein NFATC Proteins NFATC1 Protein NFATC1 Transcription Factor NFATC2 Protein NFATC2 Transcription Factor NFATC3 Protein NFATC3 Transcription Factor NFATC4 Protein NFATC4 Transcription Factor NFATL1 Protein NFATx Protein NFATz Protein Nuclear Factor of Activated T Cells 5 Protein Nuclear Factor of Activated T Cells, Cytoplasmic Nuclear Factor of Activated T Cells, Cytoplasmic 1 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 2 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 3 Protein Nuclear Factor of Activated T Cells, Cytoplasmic 4 Protein Nuclear Factor of Activated T-Cells 5 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein Nuclear Factors of Activated T Cells Nuclear Factors of Activated T-Cells OREBP Protein Osmotic Response Element Binding Protein TonEBP Protein Tonicity Responsive Enhancer Binding Protein Tonicity-Responsive Enhancer-Binding Protein Transcription Factor NF AT Transcription Factor NF-AT Transcription Factor, NFATC1 Transcription Factor, NFATC2 Transcription Factor, NFATC3 Transcription Factor, NFATC4 Transcription Factors, NFATC |
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| Tree number(s): |
D12.776.930.608 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D050778 | ||||||
| Scope note: | A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Public MeSH Note: | 2006; NFATC TRANSCRIPTION FACTORS was indexed under DNA-BINDING PROTEIN, NUCLEAR PROTEINS, & TRANSCRIPTION FACTORS 1993-2005 |
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| History Note: | 2006(1993) |
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| DeCS ID: | 51192 | ||||||
| Unique ID: | D050778 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2006/01/01 | ||||||
| Date of Entry: | 2005/06/30 | ||||||
| Revision Date: | 2013/07/09 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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NFATC Transcription Factors
- Preferred
NFAT Transcription Factor 4
- Narrower
NFAT Transcription Factor 2
- Narrower
NFAT Transcription Factor 3
- Narrower
NFAT Transcription Factor 5
- Related but not broader or narrower
NFAT Transcription Factor 1
- Narrower
| Concept UI |
M0212783 |
| Scope note | A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2. |
| Preferred term | NFATC Transcription Factors |
| Entry term(s) |
NF AT Proteins NF-AT Proteins NF-AT, Transcription Factor NFAT Proteins NFATC Proteins Nuclear Factor of Activated T Cells, Cytoplasmic Nuclear Factor of Activated T-Cells, Cytoplasmic Nuclear Factors of Activated T Cells Nuclear Factors of Activated T-Cells Transcription Factor NF AT Transcription Factor NF-AT Transcription Factors, NFATC |
| Concept UI |
M0212772 |
| Preferred term | NFAT Transcription Factor 4 |
| Entry term(s) |
Factor, NFATC3 Transcription NF AT4 Protein NF-AT4 Protein NFAT4 Protein NFATC3 Protein NFATC3 Transcription Factor NFATx Protein Nuclear Factor of Activated T Cells, Cytoplasmic 3 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein Transcription Factor, NFATC3 |
| Concept UI |
M0328766 |
| Preferred term | NFAT Transcription Factor 2 |
| Entry term(s) |
Factor, NFATC1 Transcription NF ATc1 Protein NF-ATc1 Protein NFAT 2 Protein NFAT-2 Protein NFAT2 Protein NFATC1 Protein NFATC1 Transcription Factor Nuclear Factor of Activated T Cells, Cytoplasmic 1 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein Transcription Factor, NFATC1 |
| Concept UI |
M0212771 |
| Preferred term | NFAT Transcription Factor 3 |
| Entry term(s) |
NF AT3 Protein NF-AT3 Protein NFAT3 Protein NFATC4 Protein NFATC4 Transcription Factor Nuclear Factor of Activated T Cells, Cytoplasmic 4 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein Transcription Factor, NFATC4 |
| Concept UI |
M0361472 |
| Scope note | A signal-dependent transcription factor that controls cellular response to osmotic stress. NFAT5 is closely related to NFATC PROTEINS but resides constitutively in the CELL NUCLEUS and operates independently of CALCINEURIN and TRANSCRIPTION FACTOR AP-1. |
| Preferred term | NFAT Transcription Factor 5 |
| Entry term(s) |
NFAT5 Protein NFATL1 Protein NFATz Protein Nuclear Factor of Activated T Cells 5 Protein Nuclear Factor of Activated T-Cells 5 Protein OREBP Protein Osmotic Response Element Binding Protein TonEBP Protein Tonicity Responsive Enhancer Binding Protein Tonicity-Responsive Enhancer-Binding Protein |
| Concept UI |
M0212776 |
| Preferred term | NFAT Transcription Factor 1 |
| Entry term(s) |
Factor, NFATC2 Transcription NFAT 1 Protein NFAT-1 Protein NFAT1 Protein NFATC2 Protein NFATC2 Transcription Factor Nuclear Factor of Activated T Cells, Cytoplasmic 2 Protein Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein Transcription Factor, NFATC2 |
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