| Descriptor English: | Proto-Oncogene Proteins c-kit | ||||||
| Descriptor Spanish: |
Proteínas Proto-Oncogénicas c-kit
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| Descriptor Portuguese: | Proteínas Proto-Oncogênicas c-kit | ||||||
| Descriptor French: | Protéines proto-oncogènes c-kit | ||||||
| Entry term(s): |
Antigens, CD117 CD117 Antigen CD117 Antigens Proto Oncogene Protein c kit Proto Oncogene Protein kit Proto Oncogene Proteins c kit Proto-Oncogene Protein c-kit Proto-Oncogene Protein kit Proto-Oncogene Protein, kit Receptor, Stem Cell Factor SCF Receptor Stem Cell Factor Receptor c kit Protein c kit Receptor c-kit Protein c-kit Receptor c-kit, Proto-Oncogene Protein c-kit, Proto-Oncogene Proteins c-kit, p145 kit Proto Oncogene Protein kit Proto-Oncogene Protein p145 c kit p145 c-kit p145(c-kit) p145c kit p145c-kit |
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| Tree number(s): |
D08.811.913.696.620.682.725.400.050 D12.776.476.568.400.050 D12.776.543.750.630.124 D12.776.543.750.705.852.150.100 D12.776.543.750.750.400.200.170 D12.776.624.664.700.183 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019009 | ||||||
| Scope note: | A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.10.1 | ||||||
| Previous Indexing: |
Proto-Oncogene Proteins (1989-1995) Receptor Protein-Tyrosine Kinase (1994-1995) Receptors, Colony-Stimulating Factor (1991-1995) |
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| Public MeSH Note: | 2000; see PROTO-ONCOGENE PROTEINS C-KIT 1999-1996; PROTO-ONCOGENE PROTEIN KIT (now PROTO-ONCOGENE PROTEIN C-KIT) was indexed under RECEPTOR PROTEIN-TYROSINE KINASE 1994-1995; RECEPTORS, COLONY-STIMULATING FACTOR 1991-1995; & PROTO-ONCOGENE PROTEINS 1989-1995 |
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| History Note: | 2000(1996); use PROTO-ONCOGENE PROTEIN c-KIT (NM) 1989-1995 |
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| Related: |
Piebaldism
MeSH | ||||||
| DeCS ID: | 32639 | ||||||
| Unique ID: | D019009 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1996/01/01 | ||||||
| Date of Entry: | 1995/05/26 | ||||||
| Revision Date: | 2017/05/24 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Proto-Oncogene Proteins c-kit
- Preferred
| Concept UI |
M0028387 |
| Scope note | A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis. |
| Preferred term | Proto-Oncogene Proteins c-kit |
| Entry term(s) |
Antigens, CD117 CD117 Antigen CD117 Antigens Proto Oncogene Protein c kit Proto Oncogene Protein kit Proto Oncogene Proteins c kit Proto-Oncogene Protein c-kit Proto-Oncogene Protein kit Proto-Oncogene Protein, kit Receptor, Stem Cell Factor SCF Receptor Stem Cell Factor Receptor c kit Protein c kit Receptor c-kit Protein c-kit Receptor c-kit, Proto-Oncogene Protein c-kit, Proto-Oncogene Proteins c-kit, p145 kit Proto Oncogene Protein kit Proto-Oncogene Protein p145 c kit p145 c-kit p145(c-kit) p145c kit p145c-kit |
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