DeCS

Descriptor English:

Proto-Oncogene Proteins c-met

Descriptor Spanish:

Proteínas Proto-Oncogénicas c-met

Spanish from Spain

Descriptor	proteínas protooncogénicas c-met
Entry term(s)	proteínas c-met proteínas de protooncogén c-met proteínas de protooncogén met proteínas del protooncogén c-met proteínas del protooncogén met proteínas protooncogénicas met receptor HGF receptor del factor de crecimiento hepatocítico
Scope note:	Receptores de proteína-tirosina cinasa de la superficie celular para el FACTOR DE CRECIMIENTO DE HEPATOCITOS. Constan de una cadena alfa extracelular que está unida por el disulfuro a la cadena beta transmembranaria. La porción citoplasmática contiene el dominio catalítico y sitios críticos para la regulación de la actividad cinasa. Las mutaciones en el protooncogén c-met se asocian al carcinoma renal papilar y otras neoplasias.

Descriptor Portuguese:

Proteínas Proto-Oncogênicas c-met

Descriptor French:

Protéines proto-oncogènes c-met

Entry term(s):

HGF Receptor
Hepatocyte Growth Factor Receptor
MET Proto Oncogene, Receptor Tyrosine Kinase
MET Proto-Oncogene, Receptor Tyrosine Kinase
MET Receptor Tyrosine Kinase
Proto Oncogene Proteins c met
Proto-Oncogene Proteins, met
Receptor, HGF
Receptor, Hepatocyte Growth Factor
Receptor, Scatter Factor
Scatter Factor Receptor
c Met Receptor Tyrosine Kinase
c met Proteins
c-Met Receptor Tyrosine Kinase
c-met Proteins
met Proto Oncogene Proteins
met Proto-Oncogene Proteins

Tree number(s):

D08.811.913.696.620.682.725.400.075
D12.776.476.568.400.075
D12.776.543.750.630.186
D12.776.543.750.750.400.100
D12.776.624.664.700.186

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D019859

Scope note:

Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations in the c-met proto-oncogene are associated with papillary renal carcinoma and other neoplasia.

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Registry Number:

EC 2.7.10.1

Public MeSH Note:

2006; see PROTO-ONCOGENE PROTEIN C-MET 2000-2005, see PROTO-ONCOGENE PROTEINS C-MET 1998-1999; PROTO-ONCOGENE PROTEIN C-MET was indexed under RECEPTOR PROTEIN-TYROSINE KINASE 1994-1997 & PROTO-ONCOGENE PROTEINS 1989-1993

Concept UI	M0029482
Scope note	Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations in the c-met proto-oncogene are associated with papillary renal carcinoma and other neoplasia.
Preferred term	Proto-Oncogene Proteins c-met
Entry term(s)	HGF Receptor Hepatocyte Growth Factor Receptor MET Proto Oncogene, Receptor Tyrosine Kinase MET Proto-Oncogene, Receptor Tyrosine Kinase MET Receptor Tyrosine Kinase Proto Oncogene Proteins c met Proto-Oncogene Proteins, met Receptor, HGF Receptor, Hepatocyte Growth Factor Receptor, Scatter Factor Scatter Factor Receptor c Met Receptor Tyrosine Kinase c met Proteins c-Met Receptor Tyrosine Kinase c-met Proteins met Proto Oncogene Proteins met Proto-Oncogene Proteins

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