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Descriptor English: Retinoblastoma-Like Protein p130
Descriptor Spanish: Proteína p130 Similar a la del Retinoblastoma
Descriptor proteína p130 similar a la del retinoblastoma
Entry term(s) proteína 2 similar a la del retinoblastoma
proteína RBL2
Scope note: Regulador negativo del CICLO CELULAR que sufre FOSFORILACIÓN por las QUINASAS DEPENDIENTES DE LA CLICLINA. RBL2 contiene una región pocket conservada que se une al FACTOR DE TRANSCRIPCIÓN E2F4 y al FACTOR DE TRANSCRIPCIÓN E2F5. RBL2 también interactúa con ONCOPROTEÍNAS víricas como los ANTÍGENOS DEL PAPILOMAVIRUS, las PROTEÍNAS E1A DEL ADENOVIRUS y las PROTEÍNAS E7 DEL PAPILOMAVIRUS.
Descriptor Portuguese: Proteína p130 Retinoblastoma-Like
Descriptor French: Protéine p130 de type rétinoblastome
Entry term(s): RBL2 Protein
Retinoblastoma Like Protein 2
Retinoblastoma Like Protein p130
Retinoblastoma-Like Protein 2
p130, Retinoblastoma-Like Protein
Tree number(s): D12.776.624.776.735
D12.776.660.794
D12.776.744.755
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050717
Scope note: A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. RBL2 contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and E2F5 TRANSCRIPTION FACTOR. RBL2 also interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006; RETINOBLASTOMA-LIKE PROTEIN P130 was indexed under PROTEIN 2004-2005, under ADAPTOR PROTEINS 2004, under PHOSPHOPROTEINS 1996-2004, & under PROTEINS 1994-1995
History Note: 2006(1994)
DeCS ID: 51163
Unique ID: D050717
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Retinoblastoma-Like Protein p130 - Preferred
Concept UI M0477275
Scope note A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. RBL2 contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and E2F5 TRANSCRIPTION FACTOR. RBL2 also interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.
Preferred term Retinoblastoma-Like Protein p130
Entry term(s) RBL2 Protein
Retinoblastoma Like Protein 2
Retinoblastoma Like Protein p130
Retinoblastoma-Like Protein 2
p130, Retinoblastoma-Like Protein



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