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Descriptor English: SOX Transcription Factors
Descriptor Spanish: Factores de Transcripción SOX
Descriptor factores de transcripción SOX
Scope note: Gran familia de factores de transcripción estructuralmente relacionados que fueron originalmente descubiertos basándose en su estrecha homología de secuencia con un dominio HMG-box encontrado en la PROTEÍNA DE LA REGIÓN Y DETERMINANTE DEL SEXO. Los factores de transcripción SOX  desempeñan un papel importante en la regulación de la DIFERENCIACIÓN CELULAR. Los numerosos miembros de esta familia están organizados en varios subgrupos en función de las identidades estructurales halladas en las proteínas.
Descriptor Portuguese: Fatores de Transcrição SOX
Descriptor French: Facteurs de transcription SOX
Entry term(s): SOX Family of Transcription Factors
SOX Transcription Factor Family
SRY (Sex Determining Region Y)-Box Proteins
Transcription Factors, SOX
Tree number(s): D12.776.260.719
D12.776.660.235.400.750
D12.776.664.235.400.750
D12.776.930.823
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D055747
Scope note: A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. Many SOX transcription factors play important roles in regulating CELL DIFFERENTIATION. The numerous members of this family are organized in several subgroups according to structural identities found within the proteins.
Annotation: do not confuse entry term SRY (SEX DETERMINING REGION Y)-BOX PROTEINS with SRY SEX-DETERMINING REGION PROTEIN see SEX-DETERMINING REGION Y PROTEIN
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: DNA-Binding Proteins (1992-2008)
HMG Proteins (1992-2008)
Transcription Factors (1992-2008)
Public MeSH Note: 2009
History Note: 2009
DeCS ID: 53171
Unique ID: D055747
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2009/01/01
Date of Entry: 2008/07/08
Revision Date: 2009/07/21
SOX Transcription Factors - Preferred
Concept UI M0519997
Scope note A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. Many SOX transcription factors play important roles in regulating CELL DIFFERENTIATION. The numerous members of this family are organized in several subgroups according to structural identities found within the proteins.
Preferred term SOX Transcription Factors
Entry term(s) SOX Family of Transcription Factors
SOX Transcription Factor Family
SRY (Sex Determining Region Y)-Box Proteins
Transcription Factors, SOX



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