| Descriptor English: | Retinoblastoma Protein | ||||||
| Descriptor Spanish: |
Proteína de Retinoblastoma
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| Descriptor Portuguese: | Proteína do Retinoblastoma | ||||||
| Descriptor French: | Protéine du rétinoblastome | ||||||
| Entry term(s): |
Rb Gene Product Rb Protein Rb1 Gene Product Retinoblastoma Nuclear Phosphoprotein p105 Rb Retinoblastoma Nuclear Phosphoprotein p105-Rb p105 Rb Protein p105-Rb Protein |
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| Tree number(s): |
D12.776.260.704 D12.776.624.776.745 D12.776.660.807 D12.776.744.770 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D016160 | ||||||
| Scope note: | Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein. |
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| Annotation: | /biosyn /drug eff /physiol /ultrastruct permitted |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Phosphoproteins (1990) |
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| Public MeSH Note: | 91 |
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| History Note: | 91 |
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| DeCS ID: | 29109 | ||||||
| Unique ID: | D016160 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1991/01/01 | ||||||
| Date of Entry: | 1990/06/19 | ||||||
| Revision Date: | 2005/06/30 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Retinoblastoma Protein
- Preferred
p105-Rb Protein
- Narrower
| Concept UI |
M0024673 |
| Scope note | Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein. |
| Preferred term | Retinoblastoma Protein |
| Entry term(s) |
Rb Gene Product Rb Protein Rb1 Gene Product |
| Concept UI |
M0024672 |
| Preferred term | p105-Rb Protein |
| Entry term(s) |
Retinoblastoma Nuclear Phosphoprotein p105 Rb Retinoblastoma Nuclear Phosphoprotein p105-Rb p105 Rb Protein |
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