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Descriptor English: Interferon-Stimulated Gene Factor 3
Descriptor Spanish: Factor 3 de Genes Estimulados por el Interferón
Descriptor factor 3 de genes estimulados por interferón
Entry term(s) complejo de factor 3 de genes estimulados por IFN
factor de transcripción ISGF3
Scope note: Complejo multimérico que funciona como factor de transcripción dependiente de ligandos. El ISGF3 se ensambla en el CITOPLASMA y se transloca al NÚCLEO CELULAR en respuesta a la señalización por INTERFERÓN. Consta de ISGF-3 GAMMA e ISGF3-ALFA, y regula la expresión de muchos GENES sensibles al interferón.
Descriptor Portuguese: Fator Gênico 3 Estimulado por Interferon
Descriptor French: Complexe ISGF3
Entry term(s): IFN Stimulated Gene Factor 3 Complex
IFN-Stimulated Gene Factor 3 Complex
ISGF3 Factor
ISGF3 Transcription Factor
ISGF3, Transcription Factor
Interferon Stimulated Gene Factor 3
Transcription Factor ISGF3
Transcription Factor, ISGF3
Tree number(s): D12.644.360.024.303
D12.776.157.057.061
D12.776.260.513
D12.776.476.024.386
D12.776.930.354
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050832
Scope note: A multimeric complex that functions as a ligand-dependent transcription factor. ISGF3 is assembled in the CYTOPLASM and translocated to the CELL NUCLEUS in response to INTERFERON signaling. It consists of ISGF3-GAMMA and ISGF3-ALPHA, and it regulates expression of many interferon-responsive GENES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006; INTERFERON-STIMULATED GENE FACTOR 3 was indexed under DNA-BINDING PROTEINS & TRANSCRIPTION FACTORS 1990-2005
History Note: 2006(1990)
DeCS ID: 50769
Unique ID: D050832
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2015/11/23
Interferon-Stimulated Gene Factor 3 - Preferred
Concept UI M0181861
Scope note A multimeric complex that functions as a ligand-dependent transcription factor. ISGF3 is assembled in the CYTOPLASM and translocated to the CELL NUCLEUS in response to INTERFERON signaling. It consists of ISGF3-GAMMA and ISGF3-ALPHA, and it regulates expression of many interferon-responsive GENES.
Preferred term Interferon-Stimulated Gene Factor 3
Entry term(s) IFN Stimulated Gene Factor 3 Complex
IFN-Stimulated Gene Factor 3 Complex
ISGF3 Factor
ISGF3 Transcription Factor
ISGF3, Transcription Factor
Interferon Stimulated Gene Factor 3
Transcription Factor ISGF3
Transcription Factor, ISGF3



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